Total Organic Carbon Analyzer

Laboratory analytical instruments

Total Organic Carbon (TOC) Analyzer

Testing method and principle of total organic carbon analyzer

The National Pharmacopoeia Committee recommends the use of both online and offline testing methods in Part II of the Pharmacopoeia of the People's Republic of China 2010 edition.General requirements for instruments for testing total organic carbonThere are multiple methods available for determining total organic carbon. These technologies can be used for the determination of total organic carbon in water as long as they meet the following conditions.

(1) The total organic carbon determination technology should be able to distinguish between inorganic carbon and organic carbon, and eliminate the interference of inorganic carbon on the determination of organic carbon.

(2) Should meet the requirements of system suitability testing.

(3) It should have sufficient detection sensitivity (with a low detection limit of 0.05mg/L carbon content per liter or less).

To detect the concentration of organic compounds in a sample, it is necessary to decompose and convert the organic molecules into measurable single-molecule forms. This requires oxidizing the organic compounds into carbon dioxide and measuring the resulting carbon dioxide. There are currently four methods of oxidation: first, combustion method; 2、 Photooxidation method; 3、 Wet oxidation; 4、 Photochemical method.

There are two methods for testing organic carbon after oxidation: differential method and direct method.

The expression for subtraction is TOC=TC-TIC, which means total organic carbon is the difference between total carbon (TC) and inorganic carbon (TIC).

The oxidation method used by the TA-1.0 analyzer is photooxidation:

H₂O+hn（185nm）-> OH• + H• OH• + 有机物 -> CO₂+H₂O

The measurement method for carbon dioxide is subtraction: TOC= TC － TIC

System adaptability verification

System adaptability verification is a test method for testing the oxidation ability of TOC analyzer, and its calculation formula is as follows:

Instrument response efficiency (%)=((RSS RW)/(RS RW)) * 100%

among which

rss ——Response values for 1-4 benzoquinone reference solutions;

rs ——Response value of sucrose reference solution;

rw ——Blank response value for total organic carbon detection water;

The conditions for the instrument to pass the experiment are:

85% ＜ Response efficiency ＜ 115%

Offline monitoring system TA-1.0

TA-The 1.0 Total Organic Carbon (TOC) analyzer is a high-precision offline TOC analysis instrument independently developed by our company. The instrument adopts the principle of ultraviolet catalytic oxidation, and the detection technology adopts the direct conductivity method. The total organic carbon content is calculated by measuring the change in carbon dioxide before and after oxidation. The instrument has high detection accuracy, short response time, and meets the requirements of the National Pharmacopoeia. It can meet the offline detection requirements of deionized water such as pharmaceutical water (injection water and purified water) and ultrapure water.

1.Rotating quartz glass tube coated with titanium dioxide 2.UV lamp 3.TriE Conductivity Sensor 4.Delay coil 5.peristaltic pump

performance parameters

Instrument Features

◆ No need for nitrogen, oxygen, acid reagents or oxidants, simple operation, low usage cost;

◆ Offline laboratory use, meeting the testing and cleaning verification of organic carbon in injection water and purified water;

The instrument completes audit tracking on the lower computer, with simple verification and easy query;

High degree of intelligence, equipped with an automatic sampler, system adaptability verification can be automatically completed;

◆ Limit alarm design, when the test sample exceeds the specified limit, the instrument automatically alarms;

Testing plans that comply with the new version of the national pharmacopoeia regulations can provide IQ/OQ/PQ validation services;

TA-2.0 (in/offline)

TA-2.0 Total Organic Carbon (TOC) is developed based on the existing offline TOC analysis instrument, meeting the needs of users in two different testing modes: online and offline.Online monitoring can simultaneously monitor up to three points, which is more widely used and greatly reduces the implementation cost of online monitoring for customers.

performance parameters

Instrument Features

The instrument adopts a pumpless design, and there is no need to configure a pressure reducing valve device for online detection;

Adopting high-performance CPU processors, the instrument's functions have been expanded, and processing speed and accuracy have been improved;

Large capacity storage space, which can be used for real-time querying of raw data;

High precision flow control ensures the testing accuracy and stability of TOC;

◆ No pump tube design, no need for any accessories (pressure reducing valve) online, reducing customer consumables usage, simplifying installation procedures, and ensuring more stable flow rate;

◆ Login with username and password, level 4 permissions, meeting FDA 21CFR PART 11 requirements

Our independent research and development team can design specific solutions according to customer needs.