How to clean the trough mixer after use:

1. Select the reference product. This equipment is mainly used for mixing and making soft materials of raw materials for compound Banlangen granules. Compound Banlangen is the raw material of this product, and its solubility is relatively low.

Compared to excipients, the residues of its active ingredients pose a greater threat to the quality, efficacy, and safety of the next batch of products. Therefore, the active ingredients in compound Banlangen granules should be reconstituted

Fangbanlangen has been identified as the most difficult substance to clean.

2. Verify that the equipment standard operating procedures, equipment cleaning standard operating procedures, equipment maintenance standard operating procedures, etc. used are complete.

3. Choose the most difficult parts of the equipment to clean and the sampling point. The parts that are difficult to clean during the cleaning of this equipment are: the parts connected to the rotating shaft on both sides of the inner wall of the equipment, and the uneven inner surface

At the welding point of the stirring blade. The sampling point should include the most difficult to clean area.

According to GMP requirements, the equipment must be cleaned according to the standard operating procedures for equipment cleaning at the end of each production and when changing production varieties. Cleaning of production equipment refers to checking the equipment list

The process of removing visible and invisible substances, including active ingredients, excipients, cleaning agents, lubricants, etc., from surfaces (especially the inner surfaces and components that come into direct contact with drugs)

Microorganisms and environmental pollutants, etc. To evaluate the cleaning effectiveness of the equipment, cleaning validation is required. This verification scheme is mainly applicable to the cleaning verification of CH-150 slot mixer.