In the pharmaceutical industry, innovation in production processes is key to improving drug quality, production efficiency, and cost control. Amoxicillin, as one of the commonly used antibiotics worldwide, has always been highly concerned about the optimization of its formulation process. In recent years, the application of dry granulation technology in amoxicillin production has gradually emerged and become a focus of industry attention.

Amoxicillin（Amoxicillin is a white powder with the chemical name C16H19N3O5S, a molecular weight of 365.4, and a CAS number of 26787-78-0. From the perspective of material properties, amoxicillin has a density of approximately 1.54 ± 0.1 g/cm ³ and a water solubility of 4g/L at 25 ℃. As a commonly used semi synthetic penicillin broad-spectrum β - lactam antibiotic, it occupies an important position in the pharmaceutical industry.

This antibiotic is sensitive to dampness and heat, and strict temperature control is required during the production process. Traditional wet granulation requires the addition of binders and wetting agents, and involves a drying process, which is not conducive to the production of thermosensitive drugs.

The dry granulation process does not require the addition of liquids, effectively avoiding hydrolysis and thermal degradation problems, and improving the chemical stability of the product. It is particularly suitable for drugs such as amoxicillin that are sensitive to moisture and heat. It does not require the addition of solvents, reduces the drying process, and significantly reduces the risk of drug degradation.

Simplify production process: Dry granulation eliminates the mixing, drying and other links in wet granulation, shortens the production cycle, and reduces equipment investment and operating costs. At the same time, the waste liquid treatment process has been reduced, which is in line with the concept of green environmental protection.

Improving particle performance: By adjusting parameters such as pressure and speed, dry granulation can produce particles with good flowability and uniform particle size distribution, which is beneficial for subsequent tablet or capsule filling processes and improves the quality uniformity of the formulation.

Enhance production flexibility: The dry granulation equipment has a small footprint and is suitable for continuous production and small to medium batch production. It can quickly respond to changes in market demand.

We have successively cooperated with Shandong LuKang Pharmaceutical Co., LtdThree sets of dry granulation machines, a total of 11 sets of dry granulation machines in cooperation with China National Pharmaceutical Group, and four sets of dry granulation machines in cooperation with Shanxi Shuangyan Pharmaceutical for continuous production of amoxicillin have all achieved significant results, with production efficiency increased by 30% and product qualification rate increased from 92% to over 98%. At the same time, by avoiding the use of solvents, the annual discharge of wastewater is reduced by about 200 tons, significantly reducing environmental pressure. In addition, the improvement of particle flowability significantly reduces the failure rate of the tablet pressing process and enhances equipment utilization.Our professional equipment, combined with a deep understanding of the physical properties of amoxicillin, forms the foundation for successful cooperation. Let us tailor solutions for you and work together to improve the level of pharmaceutical technology.

Welcome industry colleagues to exchange and cooperate, and jointly promote the progress of pharmaceutical technology!