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Changzhou Xianzhu Drying Equipment Co., Ltd

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Mastering the correct use of spray granulator dryer is the core to ensure product quality and production safety
Date: 2025-12-01Read: 6

Spray granulation dryer is a multi-functional pharmaceutical and chemical equipment integrating mixing, granulation and drying, which is widely used in the continuous production of tablet particles, instant drinks, catalysts, microcapsules and other products. It achieves one-step granulation by atomizing and spraying liquid adhesive into the powder in the fluidized bed, causing the powder to aggregate into uniform particles, and then rapidly drying them with hot air. However, improper operation can easily lead to uneven particle distribution, wall sticking, dust explosion, or low yield. Mastering the correct use of spray granulator dryer is the core to ensure product quality and production safety.


1、 Preparation before use: Double confirmation of materials and parameters
Raw material pretreatment: The powder needs to be sieved (usually 80-100 mesh) to ensure good fluidity and no clumping; The adhesive solution should be filtered (≤ 50 μ m) to prevent nozzle blockage;
Check the sealing of the equipment: Confirm that the lifting airbag, window, and discharge valve are sealed properly to prevent powder leakage or hot air escape;
Set process parameters: preset inlet air temperature (usually 60-120 ℃), atomization pressure (0.1-0.3MPa), fan frequency, and spray rate based on material characteristics.
2、 Startup and operation specifications
Start fluidization first, then heating: Turn on the induced draft fan and blower, wait for the powder bed to fully fluidized (in a boiling state), and then start the heating system to avoid local overheating;
Gradient heating and liquid spraying:
In the initial stage, a lower inlet air temperature (such as 70 ℃) and slow liquid spraying are used to form dense core particles;
Wait for the particles to grow to the target particle size (such as 300-800 μ m), gradually increase the drying temperature to complete solidification;
Monitoring key indicators: Real time observation of particle morphology, bed temperature, pressure difference, and dew point to ensure stable fluidization, no channeling or bed collapse.
3、 Key points of spray system operation
Selecting suitable nozzles: Two fluid nozzles are suitable for low viscosity solutions, while pressure nozzles are suitable for high solid content slurries;
Regular blowback cleaning: Automatic or manual blowback nozzle every 30 minutes to prevent crystal blockage;
Exhaust of adhesive conveying pipeline: avoid air bubbles causing interruption or pulse of spray.
4、 Dry endpoint judgment and discharge
Stable bed temperature+dew point compliance: When the moisture content of the material approaches the set value (such as ≤ 2%), the bed temperature tends to stabilize, and the dew point meter displays that drying is complete;
Cool down before discharging: Turn off the heating and introduce cold air to cool down to below 40 ℃ to prevent hot particles from absorbing moisture and clumping;
Empty the silo: Avoid residual particles becoming "seeds" for the next production, which may affect the particle size distribution.
5、 Shutdown and Cleaning
Stop spraying the liquid first, then stop the hot air: to prevent the nozzle from drying up and blocking;
CIP online cleaning (if any): Rinse the chamber, spray gun, and pipeline with purified water or cleaning agent in a circulating manner;
Disassemble the nozzle and filter bag: manually brush and dry, check for wear or deformation.