The working principle of the extrusion rolling machine mainly includes the following steps: first, mix the drug and auxiliary materials such as microcrystalline cellulose, lactose, etc. evenly, add water or solutions of PVP, HPC, HPMC or SCMC as coagulants or binders, and make the powder into a wet and uniform material with certain plasticity. Then put these materials into an extruder and squeeze them into cylindrical strips through methods such as screw pushing or rolling. Finally, place these strip-shaped objects into a rolling machine and roll them into spherical particles under the frictional and centrifugal forces of the turntable
The application of extrusion rolling machine is very extensive, mainly used for the preparation of pellets or granules. Its characteristics include stable process, high production capacity, high roundness of microspheres, smooth surface and uniform distribution. Extrusion rolling technology is suitable for mesh plates with various aperture sizes, and can extrude cylindrical strips ranging from 0.5mm to 3.0mm. In addition, the extruder can be loaded with cooling or heating jackets, suitable for continuous production of heat sensitive materials. During the rolling process, multiple motion parameters can be adjusted to ensure good process operation and product quality
The advantages of the extrusion rolling machine include high production efficiency, high yield of finished products, and flexible operation. Due to the continuous operation of extrusion rolling technology, production efficiency has been significantly improved. At the same time, the extrusion is uniform and the yield is high, resulting in microspheres with high sphericity, smooth surface, and uniform distribution of components within the spherical particles.