Biochemical analysis is one of the important methods commonly used in clinical diagnosis. Based on whether the chemical reaction between the sample and the reagent is a solid-phase chemical reaction, biochemical analysis can be divided into wet chemical method (ordinary) and dry chemical biochemical analysis. With the increasing demand for reporting emergency biochemical test results in clinical practice and the rapid development of clinical biochemical testing technology, emergency biochemical testing technology is gradually shifting from traditional wet chemistry to dry biochemistry.

Wet chemistry, also known as ordinary chemical reactions, refers to the chemical reaction that occurs when liquid reagents and samples are added to a reaction vessel and mixed together.

Dry chemistry uses multi-layer film solid-phase reagent technology. As long as the liquid sample is directly added to a reagent carrier that has been solidified in a special structure, that is, the dried reagent, water in the sample is used as the solvent to dissolve the solidified reagent on the carrier, and then it reacts chemically with the analyte in the sample for analysis and determination.

The fully automatic dry biochemical analyzer, due to its fast inspection, simple operation, and accurate results, can be used for biochemical testing in various occasions. It is widely applicable to small hospitals, outpatient departments of large and medium-sized hospitals, physical examination centers, communities, rural and other grassroots medical and health institutions.

The fully automatic dry biochemical analyzer of a company in Chengdu was recommended by the China Medical Equipment Association for the list of urgently needed medical equipment for pneumonia during the Wuhan epidemic. It has the advantages of intelligent portability, simple operation, high degree of automation, small sample size, accurate testing, and maintenance free. It can obtain test results within 12 minutes, eliminate cross contamination, and efficiently assist in the diagnosis of isolation wards and emergency cases.

The freeze-dried reagents in the dry biochemical analyzer have a shelf life of up to one year. The storage temperature is 2-8 degrees Celsius, which is convenient for storage and transportation.

The volume of freeze-dried bead packaging is generally between 1-100 μ l. At present, a major technical difficulty in the production of freeze-dried beads lies in the point liquid:

1. Trace point solution: The common point solution volume ranges from 1 microliter to 100 microliters. It is difficult for ordinary pumps that people are familiar with to continuously stabilize and ensure consistency in such a small amount of liquid.

2. High precision point solution: Freeze dried beads require high precision and shape for the point solution. When operating in the laboratory, it is often difficult to control accuracy and consistency due to manual consistency issues and simple equipment. If a regular pump is used, the controllability and accuracy of the pump are poor when handling trace amounts of liquid, which can easily result in uneven ball shapes, poor ball formation, or the ball exploding into multiple microspheres when it lands on the surface of liquid nitrogen. When the amount of liquid is small, it cannot form a uniformly shaped sphere, and when the amount is large, it is easy to separate into multiple small spheres. If the shape and size of the freeze-dried beads in the final product are inconsistent, it will affect the subsequent packaging to the reagent disk/card, detection process, and detection results.

In order to solve the high-precision liquid dispensing problem of trace fluids mentioned above, the technical team of Guangzhou Feisheng Precision Equipment Co., Ltd. has been focusing on the research and development of trace (microliter level and nanoliter level) fluid control systems since 2010, with a focus on microliter level and nanoliter level trace liquid dispensing. Based on excellent trace fluid pump technology, the DS228 desktop liquid nitrogen freeze-drying bead system has been launched, with a dispensing volume of up to 1 microliter.

The DS228 system has the technical advantages of trace (1 microliter), high precision (0.5%), high efficiency, high spherical consistency, and automated continuous production, making it the preferred system for freeze-drying bead balls in biopharmaceutical companies.

Guangzhou Feisheng Precision Equipment Co., Ltd. is a high-tech enterprise specializing in fluid precision control systems and solutions. Its professional technical team has served companies or university research institutes in the fields of bioengineering, pharmacy and medical devices in Taiwan, China, Shenzhen, Chengdu, Tianjin, Ningbo, Zhuhai, Shanghai, Xiamen and other regions of China, providing customers in China and Asia with micro fluid control system solutions with high cost performance in the industry, such as liquid dispensing, lineation, spraying, filling, etc.