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From raw materials to capsules, how to ensure the stability and consistency of the contents during the pharmaceutical process?
Date: 2025-10-16Read: 18
Guide
On the road of drug research and production, a seemingly simple capsule contains countless exquisite craftsmanship and technological accumulation behind it. The uniform dissolution and mixing of capsule contents are key factors that directly affect the quality and efficacy of drugs.
In modern pharmaceutical technology, two main techniques are used for the preparation of soft capsules:Dripping method and pressing methodThe dropping method involves wrapping the gelatin solution around the medicine and dropping it into the cooling liquid to form spherical capsules; The suppression method places the drug between two pieces of rubber and compresses it with a steel mold.Regardless of the method, it is required that the drug raw materials must be fully dissolved and mixed to ensure accurate capsule content and high bioavailability.
Dissolve and mix
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Key challenges in capsule preparation
In the process of capsule preparation, many drug ingredients need to be fully dissolved and mixed at a certain temperature to form a uniform solution or suspension. This is precisely where the shaker plays a crucial role.
These deficiencies may lead to insufficient drug dissolution and uneven mixing, thereby affecting the uniformity and stability of the capsule contents.
Click on Grant OLS-26
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Solution for capsule dissolution
Click on Grant OLS-26 circular reciprocating integrated water bath shakerRegarding the preparation process of capsules for pharmaceutical companiesDissolution and mixing requirements, provides a solution:
Click on Grant OLS-26 circular reciprocating integrated water bath shaker
1. Dual mode oscillation system, efficient mixing
■Simultaneously equipped with OLS-26Circular oscillationandReciprocating oscillationThere are two modes that can optimize the mixing effect and provide suitable mixing methods for drugs of different viscosities, ensuring sufficient dissolution and mixing of capsule raw materials.
2. Precise temperature control to ensure process consistency
Adopting digital PID temperature control and equipped with a sensitive PT1000 temperature control probe,The temperature range covers ambient temperature+5 ℃ to 99 ℃, with a stability of up to ± 0.1 ℃This ensures the dissolution process for temperature sensitive capsule materialshigh consistency.
3. excellentDesign, durable and long-lasting
The OLS-26 adopts a magnetic coupling oscillation mechanism and Heat mat heating film technology, with no heating wire inside the chamber and anti-corrosion leakage. This design not only improves the safety of the equipment, but also greatly enhances its durability and reliability.
4. Intelligent operation, safe and worry free
The device is equipped with a countdown timer with sound alarm, user-defined high temperature alarm, and power-off protection, which can ensure the accuracy of reaction time and provide sample protection. It has a high degree of intelligence and is easy to operate.
Stable performance over the years
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Reliability verification
Since a domestic pharmaceutical company introduced the Grant OLS-26 water bath shaker,The device has been running steadily for five yearsUp to now, the performance remains the sameexcellentIn the daily production process of capsules,OLS-26 plays a crucial role in promoting the dissolution of capsule ingredients, and its performance is consistently reliable.
on-site photos
Long term usage practice has proven that Diancheng OLS-26 has the following outstanding advantages:
■Low failure rateMagnetic coupling drive technology avoids the wear and tear problems of traditional transmission mechanisms, greatly reducing equipment failure rates and maintenance needs;
■ Stable operationEven within a wide speed range, stable oscillation can be maintained to ensure consistency in the dissolution process of capsule raw materials;
■Corrosion resistant designStainless steel bath and high alloy steel materials have anti-corrosion properties and are suitable for pharmaceutical laboratory environments;
■Easy to maintainThe plug and play drainage valve design and simple operating interface greatly reduce the difficulty of daily maintenance.
summary
In the field of pharmaceutical manufacturing, the reliability and accuracy of equipment are directly related to the quality and efficacy of drugs.Click on Grant OLS-26 circular reciprocating integrated water bath shaker for itsexcellentThe performance, durable design, and precise control provide reliable guarantees for the dissolution process in the preparation of pharmaceutical capsules.
Five years of stable operation is not the end point, but the starting point for achieving high-quality performance of Grant OLS-26. Choosing Grant OLS-26 is not only a choice of experimental equipment, but also a commitment to product quality and responsibility for patient safety. On the road of pharmaceutical quality, Dian Cheng OLS-26 is a trusted partner, helping pharmaceutical companies to continuously produce high-quality capsule preparations and safeguard people's health.
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