Jiangsu Guolang MachineryThe difference between dry granulation and wet granulation
1bothRaw material processing method
1. Dry granulation: In the dry granulation process, the raw materials of the drug are processed by drying, screening, etc., and then enter the granulator in the form of dry powder. After compression molding, they form granular products.
2. Wet granulation: In the process of wet granulation, the raw materials of drugs need to be mixed with a certain amount of water or other solvents to form a suspension, and then granulation is carried out by means of spray, roller, etc.
two、bothProduct Features
1. Dry granulation: Due to the relatively high density of products produced by dry granulation, the particles are relatively hard and difficult to disperse and dissolve. Therefore, dry granulation is commonly used to prepare drugs that are not easily decomposed, such as vitamins, minerals, etc.
2. Wet granulation: Due to the relatively low density of wet granulation products, their particles are softer and easier to disperse and dissolve. Therefore, wet granulation is commonly used to prepare easily decomposable drugs such as antibiotics, hormones, etc.
three、bothGranulation process
1. Dry granulation: In the dry granulation process, the granulator compresses powdered raw materials into granular products through compression molding. Due to the fact that dry granulation does not require the addition of water or other solvents, its granulation process is simple and cost-effective, but the density of the product is relatively high and easy to break.
2. Wet granulation: In the process of wet granulation, the granulator evenly sprays the suspension on the raw materials by means of spray, roller, etc., so that they can be bonded into clusters. Due to the need to add water or other solvents in wet granulation, the granulation process is relatively complex, but the density of the product is relatively low and not easily broken.
4bothComparison of advantages and disadvantages
1. Advantages of dry granulation: The granulation process is simple, the cost is low, the product density is high, and it is easy to store and transport.
2. Disadvantages of dry granulation: The product particles are relatively hard, difficult to disperse and dissolve, and prone to static electricity during the preparation process.
3. Advantages of wet granulation: The product particles are relatively soft, easy to disperse and dissolve, and the particle size and shape are easily controlled during the preparation process.
4. Disadvantages of wet granulation: The granulation process is relatively complex, the cost is high, the product density is low, and it is not easy to store and transport.
【 Conclusion 】
Dry granulation and wet granulation are two different pharmaceutical granulation processes, and their differences lie in the processing of raw materials, granulation process, and the characteristics of the final product. When choosing a granulation process, it is necessary to comprehensively consider various factors based on the properties and application requirements of the drug, and select a suitable granulation method.
For more information, please consult with Mr. Chen from the Technical Department of Jiangsu Guolang Machinery Manufacturing Co., Ltd,