How to solve the problem of difficult to crush materials that are difficult to crush? Below are several methods, hoping to help everyone.
Regarding the solution for crushing oily materials:
Due to its strong oil content, it is prone to sticking to the pulverizer and sieve during crushing, making it difficult for medicinal materials to pass through the sieve holes. Although it can be crushed together with other medicinal materials, it is easy to adhere to the pulverizer and difficult to pass through the sieve, making it prone to sticking to the pulverizer during crushing.
1. First, cut the raw ground into 2-4 mm thick slices and place them in a suitable container. Then, pour an appropriate amount of water at around 100 ℃ into the container containing the medicine Add Yi Meng Run until the medicine is completely permeable, then take it out and place it in a grinding tank to grind it into a mud like state. Then add other crushed Chinese herbs mixed into coarse powder and grind it into small pieces. After drying thoroughly at low temperature (below 60 ℃), grind it to the desired fineness.
2. 'String oil'
Oil blending: Leave the "oily" ingredients in the prescription, mix and grind other ingredients into fine powder, then gradually add the "oily" ingredients with the secondary mixed powder, and grind again. In this way, the powdered medicine can be repeatedly and timely absorbed with oil, reducing the oiliness of the powder and preventing it from adhering to the crusher and sieve holes. For example, in Bai Zi Yang Xin Wan, Bai Zi Ren, Suanzao Ren, and Schisandra chinensis are included; Ma Ren Wan or Ma Ren, bitter almonds, etc. are crushed using the "oil blending" operation.
Regarding the solution for crushing toxic materials:
Regarding medicinal herbs in poisonous dramas, such as arsenic stone, aconite, raw Sichuan black, raw grass black, raw Pinellia ternata, raw Nanxing, raw Gansui, horseradish, croton, Qianjinzi, Tianxianzi, castor bean, Yangjinhua, Naoyanghua, Acute Seed, Two Headed Sharp, wolfberry, toad, *, realgar, light powder, etc., they should be separately crushed. We believe that effective management is crucial. Strictly comply with the requirements of relevant regulations on the processing and management of medicinal materials in poisonous dramas, and establish crushing operation procedures and systems. The specific precautions for crushing medicinal herbs in poisonous dramas are as follows:
a、 The crushing of medicinal herbs in poisonous dramas should be carried out with fixed equipment and specialized management;
b、 Pay attention to crushing mechanical seals to prevent leakage;
c、 The operator should stand on the upwind side of the wind outlet, such as crushing matchworms, spotted stingers, and toads. Commonly used for operators who stand in improper positions, which can lead to poisoning or allergies;
d、 Wear a gas mask and gloves;
e、 After the crushing work is completed, the equipment and site should be cleaned immediately, and the cleaning wastewater should be properly treated;
f、 The powder packaging should have prominent and distinct toxic drug labels, and production records should be kept;
g、 Timely clean work clothes and maintain personal hygiene.
Application methods for processing other materials:
1. Application in the cosmetics industry: After crushing, the absorption time is shorter, the absorption is more complete, and the effect is more obvious.
2. Application in the animal medicine industry: (Traditional Chinese Medicine) After grinding, animal medicine can effectively improve efficacy, reduce costs, solve drug residues, and improve safety.
3. After the raw materials are crushed, they are easy to mix precisely (achieving composite and precision coating with uniformity better than ± 1 ‰).
4. The impact on drug formation (including coating):
a、 For tablets and capsules, improve dissolution rate and enhance bioavailability; Improve appearance and uniformity of particle content; Reduced fiber elasticity makes it easier to pelletize and compress; Increase the specific gravity of the capsule and increase its filling capacity.
b、 For soft capsules, improve the mixing uniformity between the main drug and the matrix, and reduce sedimentation; Due to the increase in the particle size of the main drug, the amount of matrix used can be correspondingly reduced, thereby lowering costs; Equal volume particles, thixotropy, particle size distribution, compression crushing.
c、 For ointment, gel and other external preparations, improve the mixing uniformity of the main drug and the matrix; Improve appearance delicacy, reduce particle size, facilitate transdermal absorption, and enhance therapeutic efficacy.
Special attention: Do not crush metal, especially strong and high viscosity materials.