The common problems and solutions of the eye drops filling production line are as follows:

1、 Filling accuracy issue

1. Fluctuations or deviations in filling volume

• Inaccurate metering system: Regularly calibrate flow meters or weighing sensors, and replace worn metering pump components.

• Changes in liquid characteristics: When viscosity or density is abnormal, adjust filling parameters (such as servo motor descent speed, pause delay) or replace the adapted filling head.

Valve sealing failure: Check the sealing ring of the filling valve, replace it immediately if it is aged or damaged, and clean the impurities attached to the valve.

2. Filling nozzle drip/residue

Valve closing delay: Optimize the reversing speed and closing timing to reduce liquid surface tension.

• Foreign object blockage: Stop the machine and clean the impurities in the filling nozzle to avoid crystallization or particle accumulation.

2、 Aseptic control risk

1. Microbial contamination

Insufficient environmental cleanliness: The high-efficiency filter (H14 level) undergoes regular PAO leak detection to ensure stable pressure difference in the sterile area; The wind speed in the A/B zone should be ≥ 25m/s and regularly calibrated.

• Packaging sealing defects: Replace the combination dropper plastic bottle (eliminate glass bottles) to avoid contamination caused by dropper insertion and removal.

2. Operational pollution risk

• Personnel operation loophole: Nitrogen protection throughout the filling process, operators wearing sterile clothing and operating in a standardized manner.

Incomplete equipment disinfection: CIP online cleaning is performed at the end of each batch, with a focus on cleaning the material tank, filling valve, and pipeline.

3、 Mechanical operation failure

1. Abnormal filling speed

Insufficient air pressure: Check the sealing of the air circuit and adjust the air pressure valve to the standard value of 0.4-0.6MPa.

• Solenoid valve malfunction: Clean or replace clogged/aged solenoid valves to ensure sensitive response of pneumatic components.

2. Equipment abnormal noise or vibration

Mechanical component wear: lubricate the transmission chain and bearings monthly, and tighten loose bolts.

• Power system imbalance: Verify servo motor driver parameters and replace damaged bearings or gears.

4、 Special precautions

Plastic bottle thermal sensitivity: Pre sterilized bottle body is used, and the filling temperature is strictly controlled to ≤ 40 ℃ to prevent deformation.

• Vacuum system maintenance: Regularly replace the vacuum pipeline filter element to prevent dust blockage from affecting filling efficiency.