In the field of pharmacy, the size of nanoparticles is generally defined as 1-1000 nm, and particle size is an important indicator for measuring the quality of nanomaterials, which directly affects the drug loading, stability, in vivo distribution, and targeting of drugs. Therefore, the key to the preparation of nanomaterials is to control the particle size and obtain a narrow and uniform sizeparticle size distributionHowever, there are many factors that affect particle size and its distribution, such as prescription ratiosAdditiveThe preparation process and dispersion equipment used are also key factors, such as the pH value of the medium.

High pressure homogenization equipment has always been an effective tool for preparing fine particles and emulsified products, with superior characteristics compared to previous processing methods such as ultrasound, grinding, and high-speed shearing. There are generally two types of commercially available high-pressure homogenizers: plunger type Avestin (Avestin, Ottawa, Canada) and microjet.

The plunger type high-pressure homogenizer is composed ofhigh-pressure pumpComposed of a homogenization valve, the high-pressure pump provides the required pressure to the raw material, and the homogenization valve adjusts the gap size. The depressurized material is ejected from the flow restriction gap and collides with the collision ring, producing three effects: cavitation, impact, and shear.

InNanoemulsionIn preparation, it can uniformly mix and emulsify oil and water phases, resulting in droplet sizes reaching the nanometer level. For example, in some drug nanoemulsions, high-pressure homogenization technology can highly disperse oil droplets in the aqueous phase, forming a stable system that is conducive to drug absorption and utilization.

For the preparation of liposomes, high-pressure homogenization can reduce the particle size of liposomes and control their particle size distribution. This can improve the encapsulation efficiency and stability of liposomes, enabling them to better encapsulate drug molecules and transport them to specific sites.

In terms of nanosuspensions, high-pressure homogenization technology can crush large particles of drugs into nano-sized particles, improving the solubility of drugs. For example, for some poorly soluble drugs, after being made into nanosuspensions, the dissolution rate of the drug is accelerated, thereby improving the bioavailability of the drug(The content comes from the internet. If there is any infringement, please contact us for deletion)