The small vacuum reaction kettle is the core equipment for the development of ointment and cream, with precise temperature control (± 0.5 ℃), high vacuum mixing (-0.1MPa), and modular design to ensure the smoothness and uniformity of the cream, meeting the needs from experiments to small-scale production. When selecting, it is necessary to consider both process matching and scalability, and regularly maintain to ensure the long-term stability of the equipment

In the field of pharmaceutical manufacturing, the research and production of ointments and creams require equipment, especially the vacuum reactor as the core equipment, whose performance directly affects the uniformity, stability, and safety of the product. For small and medium-sized research and development institutions or enterprises, a well-designed small complete vacuum reactor system can not only meet the process exploration in the laboratory stage, but also achieve small-scale trial production, laying the foundation for subsequent large-scale production. The following analysis will be conducted from three aspects: technical characteristics, selection points, and market status.

**High vacuum mixing technology**

The vacuum environment (-0.095MPa to -0.1MPa) can effectively remove material bubbles, prevent oxidation, and improve the fineness of the paste. By using an anchor or blade agitator with variable frequency speed regulation (adjustable speed of 20-200rpm), uniform mixing of high viscosity materials can be achieved. Some models, such as the 10L model of Ouhao Machinery, also integrate online homogenization heads to control particle size in the micrometer range.

**Modular design**
A complete set of equipment usually includes a reactor body, a vacuum pump unit, a condensation recovery device, and a PLC control system, supporting quick disassembly and cleaning. A customized product from a manufacturer in Shanghai even reserves interfaces for pH probes and viscosity sensors, making it easy to monitor process parameters in real-time.