We will present you a new type of powder preparation process - spray drying, which will enhance the efficiency of pharmaceutical enterprises. For example, spray drying at an ultra-low temperature of 35 ℃ for 1-2 seconds in an instant is mostly used for drying polypeptide drugs; Closed cycle spray drying is mostly applied to organic solvent removal drying; Open spray drying is mostly used for drying aqueous materials

After ten years of innovative research, Shanghai Qiaofeng has achieved instant (1-2 seconds) spray drying of polypeptides (such as Smeaglutide) under the condition of low temperature to 35 ℃, and continuous production to reduce costs and increase efficiency for enterprises, and has developed a safe and mature system for spray drying of organic solvents. It has now served about 2000 customer units, providing services for WuXi AppTec, Qilu Pharmaceutical, Aoruite Pharmaceutical, Jianxiang Pharmaceutical, Huahai Pharmaceutical, Nanjing Pharmaceuticals, Ningde Times, Chinalco, China Banknote, China Nuclear and many other industrial enterprises.

June 24-26 | The 23rd CPHI World Pharmaceutical Raw Materials China Exhibition

Exhibition booth introduction · Our location

Shanghai New International Expo Center-Booth Number: N3F50

Entering the Qiaofeng exhibition hall in Shanghai, we are here to help you solve the drying problem you encountered when choosing active materials or organic solvents and their mixed solvents in drug research and development?

I don't know how to effectively preserve material activity, ensure safety, be difficult to dry, meet residual requirements, meet particle size requirements, and recover organic solvents?

Main products

Main products

[Low temperature closed cycle spray drying system]

Working Principle:

1. Liquid atomization: The liquid that needs to be dried is sent into the atomization system through a peristaltic pump. In the atomization system, liquid is atomized into tiny droplets. The size of droplets is crucial for drying efficiency and quality, and typically the finer the droplets, the better the drying effect.

2. Heat exchange: These tiny droplets then enter the drying chamber and come into contact with low-temperature air that has passed through a low dew point (usually the inlet temperature can be controlled at around 35 ° C). Due to the large contact area between fog droplets and low dew point air, rapid heat and mass exchange can occur. Under low temperature conditions, this exchange can maintain the active ingredients and properties of the material, avoiding damage to the material caused by high temperatures.

3. Drying and collection: Within a short period of time, the moisture in the droplets is rapidly evaporated and taken away, while the liquid material is dried into powder form. The dried powder is collected through systems such as cyclone separators or bag filters. These systems can effectively separate powder from exhaust gas, ensuring the purity of the product.

4. Closed cycle: different from the conventional spray dryer, the low-temperature closed cycle spray dryer uses a closed cycle system. This means that (inert gas) recycling is used during the drying process. For materials handling organic solvents, the system uses inert gas media such as circulating nitrogen instead of the usual air medium to prevent combustion or explosion of organic solvents. In addition, the system also has a solvent recovery system with a solvent recovery rate of ≥ 98%, which improves resource utilization.

mainAdvantage:

1. Three functions (low temperature of 35 degrees, high temperature of 200 degrees, closed organic solvent or anti-oxidation)

①. The low temperature spray drying function is about 10 times more efficient than the lyophilizer, saving about 20 times more energy per unit output, and is suitable for heat sensitive materials (temperature as low as 35 ℃) such as protein, fungus, polypeptide and other fermented solutions

②. It is applicable to organic solvents such as solvent type, water agent and (methanol ethanol). The organic solvent spray drying function uses fully enclosed inert gas environment for drying to ensure the safety of equipment operation.

③. High temperature spray drying function is several times more efficient than conventional high temperature spray drying

2. Currently used for peptides API、 Biopharmaceutical industry such as pharmaceuticals

[Low temperature spray drying system]

Applicable solvent: water

Product granularity: Adjustable processing capacity: Equipment can be customized with 50ml-100L/H, multiple units can be connected in parallel

Temperature range: 35 ℃ -200 ℃ (high and low temperature integrated design, one device with two on top, can also be used for dry heat sterilization)

Main advantages:

① Inlet air temperature is around 35 ℃, outlet air temperature is around 25 ℃, and the material remains in a low temperature state to maintain activity

② Continuous feeding and discharging, with an efficiency about 10 times that of a freeze dryer

③ Integrated high and low temperature, one machine for multiple purposes

④ Instantly (1-2 seconds) drying

⑤ Save energy consumption, with a unit output that is about 20 times more energy-efficient than freeze-drying machines.

[Closed cycle spray drying system]

Applicable solvents: various organic solvents or mixed solvents (tetrahydrofuran requires special instructions)

Processing capacity: 0.5L-200L/H, customizable according to actual requirements and situations

Temperature range: Designed according to solvent type, both low-temperature and high-temperature solvents can be dried and recovered. Solvent recovery rate: ≥ 98%

Dissolved residue:<1000ppm, as low as 0ppm.

mainAdvantage:

① System design is secure and mature

② Energy saving design

③ Solvent recovery rate ≥ 98%

④ Residual dissolution meets requirements, no need for secondary drying, reducing transportation risks

⑤ Having a mature system simulation library

⑥ Experienced in the pharmaceutical industry