Emulsifier plays an important role in the pharmaceutical industry

1、 Introduction to Taicang Xide Mechanical Emulsifier

The three-stage high shear dispersion machine is mainly used for the production of micro lotion and ultra-fine suspension lotion. Since three groups of dispersion heads (stator+rotor) in the working chamber work at the same time, after high shearing, the lotion drops are more delicate and the particle size distribution is narrower, so the stability of the generated mixed liquid is better. The three sets of dispersing heads are easy to replace and suitable for different process applications. The different models of machines in this series have the same line speed and shear rate, making it very easy to scale up production. It also meets the CIP/SIP cleaning standards and is suitable for food and pharmaceutical production. High rotational speed and shear rate are important for obtaining ultrafine suspension lotion. According to some industry specific requirements, its shear rate can exceed 18000rpm, and the rotor speed can reach 51m/s. Within this speed range, turbulence caused by shear forces combined with specially developed motors can reduce the particle size range to the nanometer level. The shear force is stronger, and the particle size distribution of lotion is narrower.

2、 Performance advantages of ultra high speed emulsifier

During the operation of the ultra high speed emulsification equipment, new interfaces are constantly generated in the material, resulting in cutting, compression, folding turbulence, and other effects, thereby causing the material to flow towards the high shear three-stage emulsifier. The material is subjected to hundreds of thousands of hydraulic shearing, squeezing, mixing, spraying, high-frequency oscillation and other comprehensive actions per minute in the narrow gap between the stator and rotor, rapidly breaking into particles of 200nm-1um. Due to the vacuum state inside the emulsification tank, the bubbles generated during the mixing process of the material are promptly removed. After high-frequency cycling, the materials in the entire container are continuously mixed, dispersed, homogenized, and emulsified from top to bottom, resulting in high-quality products that are bubble free, delicate, and stable. Material granulation, emulsification, mixing, blending, and dispersion can be completed in a short period of time. The contact area with the material is made of stainless steel (316L material is used for medical purposes, with a mirror polished inner surface, and the vacuum stirring device is hygienic and clean. It is manufactured according to hygiene standards that comply with GMP regulations.

3、 Application of Emulsifier in Pharmaceutical Industry

Emulsifiers play an important role in the stirring system of pharmaceutical industry equipment, especially in solid-liquid mixing, liquid-liquid mixing, oil-water emulsification, dispersion homogenization, and shear grinding, which have extremely important applications. The reason why it is called an emulsifier is because it can achieve emulsification. The lotion is formed after the mixing of oil-water two-phase media, which can be divided into two systems: water in oil or oil in water. To achieve emulsification, there are at least two requirements: one is strong mechanical cutting and dispersion. The fluid media of water phase and oil phase are cut and dispersed into small particles at the same time, and then when they are gathered and combined, they will permeate and mix with each other to form lotion. The second is suitable emulsifier, which acts as a medium bridge between oil-water molecules. Through its charge and intermolecular force, oil-water mixed lotion can be stored stably according to the time we need. Nowadays, the application of emulsifiers is not limited to "emulsification". Due to its shearing effect, it crushes and impacts the powder particles in the liquid to refine them to the ideal particle size, thereby fully mixing the solid matter into the liquid and forming a relatively stable suspension. This process is also known as "dispersion". Of course, like emulsifiers, the stability of the suspension can be enhanced by adding dispersants. When a solid substance can be dissolved by a liquid * after a certain period of contact, the small particles formed by shear impact will be dissolved by the liquid faster because their specific surface area has increased many times.

3、 Parameter Table of High Shear Emulsification Equipment for Xide

Emulsifier plays an important role in the pharmaceutical industry