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What are the factors that affect the granulation process of high-speed mixing granulators?
Date: 2024-05-14Read: 4
Compared with other traditional granulation processes, wet mixed granulation has irregular particle shape, uniform particle size distribution, and complete structure. However, the finished product is influenced by many factors, which the editor will briefly describe belowThe impact of laboratory hopper mixerfactor:
1. The influence of stirring blade and tool speed
It can be said that the size and distribution of particle size are directly related to the rotational speed of the stirring blade and cutting knife. When the cutting speed is low, the particle size increases, while when the speed is high, the particle size decreases. When the impeller speed is low, the particle size is smaller; When the speed is high, the particle size is larger, and the two have opposite effects.
2. Effects of materials and concentrations
In wet mixed granulation production, alcohol granulation or dextrin binder granulation are usually used, but the viscosity of the two is different. Usually alcohol is used for granulation, with small and fine particles that are easy to dry. Due to the non stickiness and loose action of alcohol, this method is an ideal way to pellet high viscosity traditional Chinese medicine. If using paste to refine particles, the particles will be large, rough, and dry slowly. This method is ideal for Western medicine without viscosity, as cyclodextrin has viscosity and polymerization properties.
3. The influence of mixing, granulation procedures and time
During the operation of the high-speed mixing granulator, the rotation of the stirring blade causes the material inside the pot to roll into the space, causing the material at the bottom of the pot to rotate and be thrown along the pot wall. This action pushes the soft material one by one towards the fast cutting machine and cuts it into particles of different sizes. After rolling with each other for a period of time, the particles become round and gradually become spherical. It can be seen that the speed and time of the stirring blade and cutting knife have an impact on the particle size.
In addition, whether using diluted concentrated extracts as materials or using dextrin or other adhesive materials, the slurry concentration of the material can be lower when producing smaller particles, and higher when larger particles are needed.
