SPACE peptide is a type of skin penetrating peptide (SPPs). SPACE peptide can enhance the local delivery of large molecule hyaluronic acid. When SPACE peptides are coupled with carriers such as small molecules and proteins, they can promote their penetration into the stratum corneum and enter the epidermis and dermis. SPACE peptides also exhibit higher permeability to various cells, including keratinocytes, fibroblasts, and endothelial cells, which is likely achieved through the macropytic pathway SPACE peptide enhances the skin penetration of cyclosporine A through a cross cellular pathway, while binding to keratin and cyclosporine A, promoting its distribution in keratinocytes rich in keratin.

CAS number: 1621717-95-0

Chinese name: SPACE peptide

English name: SPACE peptide

Amino acid sequence: Ala Cys Thr Gly Ser Thr Gln His Gln Cys Gly (disulfide bond: Cys2-Cys10)

Single letter sequence: H2N-ACTGSTQHQCG-OH (Disulfide Bridge: C2-C10)

Three letter sequence:

H2N-Ala-Cys-Thr-Gly-Ser-Thr-Gln-His-Gln-Cys-Gly-OH(Disulfide Bridge:Cys2-Cys10)

Molecular weight: 1090.15

Molecular formula: C40H63N15O17S2

Isoelectric point: The net charge at pH 7.0 is 3.15

Supplier: Xi'an Kaixin Biotechnology Co., Ltd

Structural formula:

Purity: ≥ 95%

Security protection:

During the operation, disposable protective clothing, masks and other protective equipment should be worn to ensure self safety.

This reagentonly useIn scientific research

[Mechanism of Action]

SPACE peptides, as a type of skin penetrating peptide (SPPs), have the core function of enhancing the local delivery ability of macromolecules. When combined with "goods" such as small molecules and proteins, it can help these substances penetrate the stratum corneum and enter the epidermis and dermis layers. Research has shown that it may be able to enhance its permeability in various cells, such as keratinocytes, fibroblasts, and endothelial cells, through the macropytic pathway. In terms of enhancing the skin penetration of cyclosporine A, it binds to both keratin and cyclosporine A through a cross cellular pathway, increasing the distribution ratio of cyclosporine A in keratin rich keratinocytes and promoting its penetration.

Advantages

Efficiency: significantly improves the transdermal efficiency of large molecules and reduces the demand for dosage.

Safety: The cyclic peptide structure is stable, biocompatible, and has low toxicity.

Flexibility: It can covalently bind with other functional molecules (such as fluorescent labeling and targeted ligands) to achieve multifunctionality.

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The above content is edited and organized by YNN of Xi'an Kaixin Biotechnology Co., Ltd

This reagent is only used for scientific research experiments and cannot be used on the human body