HZ PEG anisamide (hydrazide polyethylene glycol anisamide) is a cleverly designed three function targeted delivery tool, consisting of three core functional modules:

Hydrazide end (- NH-NH ₂): As a biological coupling handle, the hydrazide group can undergo efficient and rapid covalent reactions with molecules containing aldehyde or ketone groups, forming stable hydrazone bonds. This reaction is usually carried out under mild acidic conditions and is a classic method for connecting drugs, fluorescent probes, or nanoparticles.

PEG linking arm: PEG (polyethylene glycol) plays a crucial role as a multifunctional regulator in HZ PEG anisamide. It can not only increase the water solubility of the entire molecule and the final conjugate, provide steric hindrance to reduce mutual interference between different functional modules, but also prolong the cycle time. When attached to the surface of nanocarriers such as liposomes and polymer micelles, PEG can form a "hydration layer", reducing its clearance by the immune system and achieving long-term circulation. In addition, the length (molecular weight) of PEG chains can be adjusted, affecting the distance between the targeted ligand and the carrier surface, thereby optimizing the binding efficiency with the target.

Anisamide end: As an active targeting head group, anisamide is a derivative of methoxybenzamide and a high affinity ligand for sigma-1 receptors. This characteristic enables HZ-PEG-anisamide to specifically target cells or tissues expressing sigma-1 receptors, achieving precise delivery.

Chinese name: Hydrazide polyethylene glycol anisamide

English name: HZ PEG anisamide; Hydrazide-PEG-anisamide

分子量： 0.4k，0.6k，1k，2k，3.4k，5k，10k 等（支持定制）

Purity: ≥ 95%

Appearance: Solid powder or granules

Solubility: soluble in some organic solvents and water

Storage conditions: Freeze and dry below -20 ℃ to avoid repeated freeze-thaw cycles

Packaging specifications: 1g, 5g, 10g

Security protection:

During the operation, disposable protective clothing, masks and other protective equipment should be worn to ensure self safety.

This reagentonly useIn scientific research

Add image annotation, no more than 140 words (optional)

Stability and Storage Conditions

Stability: HZ PEG anisamide has high stability in solid powder or particle state. However, in the solution state, its stability may be affected by factors such as temperature, light, pH value, etc. Therefore, it is necessary to pay attention to controlling these conditions during use to maintain its stability.

Storage conditions: In order to maintain the long-term stability of HZ PEG anisamide, it is recommended to store it in a frozen and dry environment below -20 ℃ and avoid repeated freeze-thaw degradation. Meanwhile, the storage process should avoid the influence of light and humid environment.

【 Related reagents 】

N3-PEG-PAsp

mPEG-PLA-PLL

NH2-PEG-PPHE

NH2-PEG-DSPE

NH2-HANH2-HA

N3-PEG10000-PLL70-80

mPEG-PPHEmPEG-PPHE / mPEG-PPHE

Azide-PEG-MannoseN3-PEG-Mannose

PEI-PCL-NHSPEI-PCL-NHS / PEI-PCL-NHS

mPEG-TK-PCLmPEG-TK-PCL PCL-TK-mPEG

NHS-PEG-PLGNHS-PEG-PLG / NHS-PEG-PLG

OH-PLGA-OHOH-PLGA-OH / OH-PLGA-OH

PEI-PCL-FolatePEI-PCL-Folate / PEI-PCL-Folate

mPEG-PLA-PEImPEG-PLA-PEI / mPEG-PLA-PEI

PEI-PCL-COOHPEI-PCL-COOH / PEI-PCL-COOH

PBLA-PEG-PBLAPBLA-PEG-PBLA / PBLA-PEG-PBLA

PAsp-PEG-AzidePAsp-PEG-Azide / PAsp-PEG-Azide

NH2-PEG-FluoresceinNH2-PEG-FITC / NH2-PEG-FITC

The above content is edited and organized by YNN of Xi'an Kaixin Biotechnology Co., Ltd

This reagent is only used for scientific research experiments and cannot be used on the human body