MPEG-PO-PCL-PO-mPEG is a pentablock copolymer consisting of the following components:

Two ends: methoxy polyethylene glycol (mPEG) segments, providing hydrophilicity and biocompatibility.

Middle: PCL segment, endowed with hydrophobicity and biodegradability.

Connection bridge: Polyoxypropylene (PO) units connect mPEG and PCL through chemical bonds to form a symmetrical pentagonal structure.

Key design highlights:

PO Link Bridge: Introducing enzymatically degradable chemical bonds such as phosphate ester bonds to enhance the targeted release ability of materials under specific conditions such as tumor microenvironment.

Symmetry: The dual mPEG end design forms an "invisible" coating, reducing plasma protein adsorption and prolonging in vivo circulation time.

Chinese name: Methoxypolyethylene glycol - polyoxypropylene - polycaprolactone - polyoxypropylene - methoxypolyethylene glycol

English name: mPEG-PO-PCL-PO-mPEG; Methoxy PEG-PO-PCL-PO-Methoxy PEG

分子量： 0.4k，0.6k，1k，2k，3.4k，5k，10k 等（支持定制）

Purity: ≥ 95%

Appearance: Solid powder or granules

Solubility: soluble in some organic solvents and water

Storage conditions: Freeze and dry below -20 ℃ to avoid repeated freeze-thaw cycles

Packaging specifications: 1g, 5g, 10g

Structural formula:

Security protection:

During the operation, disposable protective clothing, masks and other protective equipment should be worn to ensure self safety.

This reagentonly useIn scientific research

Biological performance and advantages

Biocompatibility: mPEG has low immunogenicity and PCL degradation products are non-toxic, making it suitable for in vivo applications.

Controllable degradation: By adjusting the length of PCL, the degradation rate can be controlled to achieve long-term release of drugs or growth factors.

Stealth effect: The outer layer of mPEG can reduce protein adsorption and macrophage recognition, prolonging the circulation time of nanocarriers in the blood.

Functionalization potential: Terminal or connecting units can modify targeted ligands, fluorescent labeling, etc., achieving multifunctionality.

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The above content is edited and organized by YNN of Xi'an Kaixin Biotechnology Co., Ltd

This reagent is only used for scientific research experiments and cannot be used on the human body