the 6th Special Training on Freeze Drying Technology

-----STARLe Jiawen co-host Location: Shanghai

Date: November 30th and December 1st (two days in total)

-----Let's explore Chinese craftsmanship, move towards Chinese amplification, and move towards production

Freeze drying technology can significantly improve drug stability, improve product storage conditions, and extend product shelf life, making it widely used in the pharmaceutical and food industries.

Before and during the exploration of freeze-drying process, if there is a complete theoretical system to guide, it will greatly shorten the time for R&D personnel to explore the process. And solve the problems encountered during the freeze-drying process.

STARThe freeze-drying laboratory located at the headquarters in Spain,16Over the years, we have provided customers with freeze-drying process design, optimization, freeze-drying process scaling up, and validation services. Accumulated experience in exploring hundreds of processes and formed a complete theoretical system of its own.

1130th of the month
8:30Start signing in
9:00-11:45	Physical concepts during freeze-drying process
	Vacuum measurement
	temperature measurement -The principle of temperature measurement using different types of probes; -Analysis of temperature measurement deviation sources; -Automatic Product Sublimation Interface Temperature Acquisition Based on Mathematical Modeling - LyoMetrix Software
	Freeze drying steps
	How to design an initial freeze-drying formula for a new product
	How to optimize freeze-drying formula ---The relationship between the temperature of the laminate, the vacuum degree of the system, the sublimation interface temperature of the product, and the sublimation rate during a drying process.
buffet lunch
13:00-17:00	Mechanical design and performance of freeze-drying machine ---Craft exploration type Chinese freeze-drying machine ---Small scale production type Chinese freeze-drying machine ---Special design for special applications
	LYOTRIS ultra small scale production freeze-drying machine designed specifically for high value-added drugs ---Integrated structure, ultra small footprint ---Multiple redundant sets to ensure sample safety ---Intelligent software with multiple new features added together Large scale production freeze dryer - LYOMEGA Automatic loading and unloading system for industrial freeze-drying machine
	Verification of Freeze Drying Machine ---performance verification ---File verification
	Discussion for 30 minutes
12On the 1st of the month
9:00-11:45	Pre freezing ---The influence of undercooling temperature on nucleation ---Factors affecting subcooling temperature: cooling rate, cleanliness, etc ---Applicable processes and operating methods for annealing and SOAK ---Instant crystallization technology: ice mist method, positive pressure method, negative pressure method ---STAR LYONUC vacuum assisted nucleation technology
	The combination of Chinese freeze-drying equipment and PAT tools ---Automatic acquisition of different temperature probes and sublimation interface temperatures ---The impact of gas infiltration on the manufacturing process ---BARATRON capacitance vacuum gauge quickly helps find the endpoint of freeze-drying ---Application of Dew Point Probe ---Online weighing ---Automatic pressure rise test
	Discussion for 30 minutes
buffet lunch
13:00-17:00	Using the method of approximate spatial design (QbD), step-by-step process scaling is carried out ---Experience in the process of Chinese amplification ---Analyze the impact of different environments, equipment, thermal radiation, and other conditions on amplification one by one ---Experimental design for sublimation testing between different devices ---Using the method of approximate spatial design, find the amplification conditions and formula for zuiJIA
	The impact of freeze-drying containers on the freeze-drying process and products
	Discussion for 30 minutes

The course is over, but our service is far from over……. .

---After the course ends, the following will be established:Discussion group on freeze-drying process exploration technology

Users who participate in the training can use the problems encountered in their work to illustrate+The form of text Send to the group.

starHead of Freeze Drying Equipment China Region Kang Yu will regularly summarize the questions in the group and submit them to the Spanish freeze-drying process laboratory for answers.

Regularly answer typical questions in the group every month.

We will always be by your side…………..

STARGroup Profile

STAR 1963Established in Barcelona, Spain.1964Produce * industrial freeze-drying machines annually for use in the pharmaceutical industry. One of the three major industrial freeze-drying machine suppliers in Europe. So far, there have been53The production history of freeze-drying machines.

2001In the year, a freeze-drying process laboratory was established at the headquarters located in Barcelona. Assist clients in developing freeze-drying formulas and conducting research on new freeze-drying technologies. All experimental curves and data in the following training content are real experimental data from the freeze-drying laboratory.

Introduction to the Author of Freeze Drying Process Training Textbook

Robert BullichPh.D.

　　Robert BullichThe doctor isSTARThe founder and head of the group's freeze-drying research and development laboratory, possessing16Years of experience in freeze-drying process research.Robert BullichThe doctor has accumulated extensive practical experience in freeze-drying research and development, and has successfully developed and designed freeze-drying formulas for the following products:

Gastric protectants::Omeprazole, Pandora's azole, esomeprazole

antibiotic: Piperacillin, Triazobactam, Vancomycin, Fluconazole,

Cytotoxins:SILEIMEISU， Gemcitabine , Yina Tong, etc

Food industry: Devoted to the development of various freeze-dried product formulas, such asThe BullyRestaurant, fruits, fish, meat;Zafronrestaurant,Lactic acid bacteria, milkCellar of Can Rocarestaurant

QIGUANYIZHI: Skin, Tendons

API: Terlipressin with various cyclodextrins and tert butanol as solvents Freeze drying of raw materials

Allergy preparations: multiple formulas

Vaccines: Multiple formulations Blood derivatives: Fibrinogen, some factors

Reagents: Multiple formulations

Course language:

English+Chinese translation

cost:

-course2500yuan/People,4000 yuan/two people

-Including information and lunch expenses

-Excluding round-trip travel expenses and accommodation

Issue invoices for technical service fees and consulting fees

Organizer：AZBIL STAR TECHNOLOGIES. S.L.U

LeJiaWen Pharmaceutical Technology Co., Ltd

Course address:Xinjun Ring Road, Pujiang Town, Minhang District, Shanghai158number1building 304room

(Le Jiawen Shanghai Office First floor conference hall)

Nearby agreement hotels:

Pujiang Zhixuan Holiday Hotel

Hotel address: Puxing Road, Pujiang Town800numberAbuilding

If you need to book a contracted hotel, you canLINDAAssist in booking.

Registration Receipt

(Each person should fill in one copy, and photocopies are valid)

Will you participate in this seminar □ Yes □ Course 2500yuan/person □4000yuan/two people
Name		position
employer
address
Dietary restrictions	□ None □ Yes, please indicate
Do you need assistance in booking a hotel

2Please fill in the registration receipt in detail and fax or email it before November 25, 2017