The transdermal diffusion analyzer can help you accurately evaluate the transdermal effect of drug or cosmetic ingredients, optimize formula design, and ensure product safety and effectiveness. It mainly solves the following problems:

1、 In the field of drug research and development

1. Transdermal property evaluation
   By simulating the human skin environment and accurately measuring the rate and quality of drug penetration through the skin, it helps evaluate transdermal properties and bioavailability, optimize drug formulations and formulation processes.

2. Multi condition simulation and experimental optimization
   Support adjusting parameters such as temperature, humidity, and drug concentration, simulate the transdermal process of different skin types (such as dry and oily skin), different parts (such as the face and limbs), and different environmental conditions (such as high temperature and high humidity), and comprehensively understand the transdermal behavior of drugs in different scenarios.

3. Easy to operate and reliable data
   Equipped with high-precision sensors and advanced data processing technology, real-time monitoring and recording of drug transdermal processes ensure data accuracy and repeatability. The automated operation process and user-friendly interface simplify experimental operations, reduce human errors, and improve experimental efficiency.

2、 Development of daily chemical products

1. Research on transdermal absorption of cosmetic ingredients
   Used to test the permeability and absorption of functional ingredients (such as moisturizers, whitening agents, anti-aging ingredients), providing scientific basis for product safety and effectiveness evaluation.

2. Compliance and standardization support
   The design complies with international standards such as USP, EP, JP, etc., meeting the requirements of the pharmaceutical industry for data integrity. Its audit tracking, permission management, and electronic signature functions ensure the traceability and compliance of experimental data, providing technical support for the entry of daily chemical products into the international market.

3、 Applicable formulations and application scenarios

1. Applicable formulations
   Including transdermal patches, gel, creams, ointments and other external preparations.

2. Application scenarios
   Covering drug research and development institutions, drug inspection institutions, and R&D and quality control departments of pharmaceutical companies.

4、 Operation process and precautions

1. Operation process
   Before use, it is necessary to prepare drug samples, receiving media, skin (or artificial membrane) and other materials required for the experiment, and clean and disinfect the diffusion pool. Inject the receiving medium into the receiving chamber to ensure no residual bubbles, then fix the skin (or artificial membrane) flat between the two chambers of the diffusion pool, and apply an appropriate amount of sealant to prevent leakage. Subsequently, evenly apply the drug sample onto the skin (or artificial membrane) surface of the supply chamber, cover the supply chamber lid tightly, install the diffusion cell onto the instrument, and set experimental parameters (temperature 32 ℃, stirring rate 500r/min, sampling time points 0.5h, 1h, 2h, 4h, 8h, 12h, 24h). After starting the instrument, take samples from the receiving room at the set time point, and replenish an equal amount of fresh receiving medium after sampling to maintain a constant volume of the receiving room. After sampling is completed, the drug concentration in the sample is analyzed using equipment such as high-performance liquid chromatography to calculate the transdermal rate and permeation rate.

2. Precautions
   The skin (or artificial membrane) needs to be kept intact and undamaged, otherwise it may cause direct drug leakage and affect the accuracy of the experiment. During the experiment, real-time monitoring of temperature and stirring rate is required. If the temperature fluctuation exceeds ± 0.5 ℃, the instrument parameters should be adjusted in a timely manner. The receiving medium needs to be prepared and used immediately to avoid changes in composition due to prolonged storage time.

5、 Instrument structure and core components

The drug transdermal diffusion tester mainly consists of a diffusion cell, temperature control system, magnetic stirring system, sampling device, and data recording system.

6、 Standardization selection and processing of skin models

1. Prioritize choosing Bama fragrant pig skin
   Bama fragrant pig skin is recommended as the "gold standard" model for IVPT due to its high similarity to human skin in terms of stratum corneum thickness (15-20 μ m), hair follicle density (11-14/cm ²), and lipid composition (ceramide content similar to that of humans).

2. Skin integrity verification
   The integrity of the skin barrier needs to be verified before and after the experiment using transcutaneous water loss (TEWL) or impedance spectroscopy.

3. Preservation and activity maintenance of ex vivo skin
   The ex vivo skin of Bama fragrant pig should be used within 24-48 hours to avoid damage to the stratum corneum structure caused by cryopreservation. Before the experiment, the skin temperature needs to be balanced to 32 ℃± 0.5 ℃ to simulate physiological conditions.

7、 Experimental Design and Operating Standards

1. Selection and calibration of diffusion pool
   The diffusion cell is the core component, commonly known as the Franz diffusion cell, consisting of a supply chamber (volume 1-5ml) and a receiving chamber (volume 5-20ml), mostly made of glass or stainless steel.

2. Experimental parameter settings
   The experimental parameters include temperature of 32 ℃, stirring rate of 500r/min, sampling time points of 0.5h, 1h, 2h, 4h, 8h, 12h, and 24h.

3. Data recording and analysis
   Analyze the drug concentration in the sample using equipment such as high-performance liquid chromatography, and calculate the transdermal rate and permeation rate.