Technical characteristics and innovative practices of small-scale experimental dry granulation machines:
1、 Core process characteristics
• Solvent free dry pressing molding: Directly using the crystallization water of the material to complete the pressing, avoiding the problem of solvent residue in wet granulation, especially suitable for the processing of thermosensitive traditional Chinese medicine extracts and antibiotic raw materials.
Micro testing capability: The feasibility of the formula can be verified with a minimum of 5 grams of material. The hydraulic system, combined with precision sensors, can achieve 0.1mm level roll gap adjustment, providing high-precision data support for the research and development stage.
Double stage feeding system: Vertical hinge dragon pre compression and horizontal screw collaborative feeding significantly improve the filling uniformity of lightweight powders (such as micro powder silica gel), with density fluctuations controlled within ± 3%.
2、 Technological innovation breakthrough
Intelligent control module: PLC touch screen integrated pressure speed linkage algorithm, real-time monitoring of pressure roller temperature and water cooling system status, ensuring that the activity of heat sensitive materials is not damaged.
Transparent operation design: The 316L stainless steel sealed chamber is equipped with a visual observation window, which meets both GMP cleanliness requirements and experimental process visualization needs.
Circulating dust removal technology: Equipped with a built-in cyclone separator to recover undersized powder, the material utilization rate reaches over 98%, reducing losses by 40% compared to traditional equipment.
3、 Cross disciplinary application expansion
The current equipment has broken through the boundaries of the pharmaceutical industry and demonstrated potential in scenarios such as microencapsulation of food seasonings and pre molding of magnetic materials. In the future, AI process parameter self optimization systems will be used to further shorten the conversion cycle from laboratory to industrialization.