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Zhejiang Canaan Technology Co., Ltd
Case of Budesonide Enteric coated Capsules (Part 2) | Analysis of Micro pill Filling and Hard Capsule Sealing
Date: 2025-12-18Read: 0
In the production of budesonide enteric coated capsules,Accurate filling of microspheres and reliable sealing of capsulesTo ensureUniform drug dosage and intact enteric barrierThe key link. These two processes directly determine whether the final product can be producedSafely reach the intestine and accurately release.
C· Micro pill filling: precise quantification, non-destructive filling
Accurately filling the microspheres wrapped in three layers of sustained-release coating into capsules is the core step in controlling the final dosage. The CAP series hard capsule filling machine provides an efficient and precise solution for this.
► Its optionalIndependent pellet filling stationHas the following characteristics:
👉 Flexible switching:The pellet and powder filling stations can be quickly replaced without the need for repeated disassembly and assembly of the transmission structure, adapting to the production of multiple varieties.
👉 Gentle handling:Adopting push plate filling, the stroke is short and the force is slow, which greatly reduces the wear of the micro pill coating layer,The wear rate of the slow-release layer is less than 0.2%Protect the drug release characteristics.
👉 Accurate dosage:Equipped with adjustable measuring molds with an adjustment range of up to 60%, it can flexibly adapt to different loading requirements,Stable control of loading deviation within 2%.
👉 Smooth cutting:The filling plate can be equipped with a vibrator to effectively eliminate the "bridging" and electrostatic adsorption between microspheres, ensuring a continuous and stable filling process.
C· Capsule sealing: firm sealing, exquisite appearance
The filled capsules need to be sealed not only for aesthetic purposes, but also to ensure that the capsule shell is tightly closed during subsequent enteric coating and transportation storage, preventing moisture or leakage of the contents.
► NSF800 Capsule Sealing MachineProvide reliable assurance for this process:
👉 Uniform gluing: Using secondary gluing technology, the distribution of glue is more uniform, and the sealing line is firm and beautiful.
👉 Accurate temperature control: The rubber box adopts insulation design, combined with high-sensitivity temperature sensors, to achieve real-time and precise control of the temperature of the adhesive liquid, ensuring safe and stable operation.
👉 Easy to clean: The rubber box and the main unit are connected by a pneumatic clutch, which can be easily disassembled and cleaned, meeting GMP requirements.
👉 Non destructive conveying: The precise capsule chain plate conveying mechanism, combined with a fully enclosed low-temperature drying system, ensures that the capsules are arranged in an orderly manner during transportation and drying, without damage, and without affecting drug stability.
The precise filling of microspheres and reliable sealing of capsules jointly construct a dual guarantee of uniform internal content and complete and stable outer shell of budesonide enteric coated capsules. passHighly automated and refined equipment solutionsBeing able to contribute to thisThe large-scale and high-quality production of formulations provides a solid foundation.
C· From experimentation to mass production, Canaan provides validated process pathways
Canaan Technology Solid Formulation Experimental Center is equipped withA complete experimental platform from small-scale to pilot scale testingWe can provide customers with:
✅ Development and parameter optimization of hard capsule enteric coating process;
✅ The overall connection test with the process of drug loading and capsule filling in fluidized bed microspheres;
Output process solutions based on real cases to shorten customer project cycles.