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Balance weighing cover bag in bag out
Date: 2025-04-16Read: 9
In pharmaceuticals or physical and chemical applicationsIn the laboratory, weighing is a crucial step in the entire R&D analysis chain. Safety protection during weighing process and accurate and efficient weighing resultsIt is crucial for the health of researchers and the advancement of research projects.In the pharmaceutical industry, weighing experiments involve drugs or intermediates with certain activity, toxicity, allergenicity, and teratogenicity.
In laboratory weighing operations, there are usually the following pain points:
1. Environmental sensitivity can lead to unstable weighing, air flow interference, and fluctuations in high-precision balance readings caused by laboratory ventilation systems or personnel movement (especially in micro weighing);
2. Balance is sensitive to temperature and humidity, and environmental changes can easily cause drift (such as thermal expansion and contraction leading to changes in sample or container quality);
3. Accidentally spilled during the transfer of powder or liquid, or if the container is not functioning properlythoroughlyCleaning leads to cross contamination.
4. There are various types of active drugs involved in the operation, each with different health hazards.
Occupational Exposure Band (OEB) refers to the relative risk level of chemical exposure caused by work activities in an occupational environment. It complements Occupational Exposure Level (OEL), which refers to the maximum acceptable concentration limit. The concept of OEB was first introduced by the US Occupational Safety and Health Administration（OSHA）Established based on the proposal of the American Conference of Industrial Hygienists (ACGIH) to guide the determination and calculation of appropriate exposure limits.
According to the EU Directive 89/391/EEC and the latest regulations on dangerous goods, it is necessary to implement collective safety measures, especially in closed systems. This means that the entire process from production to final product packaging should be carried out in a sealed environment to ensure the safety of workers.
The "EHS Guidelines for the Chinese Pharmaceutical Industry" formulated by the China Pharmaceutical Enterprise Management Association. This EHS guideline states that the pharmaceutical industry typically involves drugs or intermediates with certain activity, toxicity, allergenicity, and teratogenicity in the drug production process, and their occupational exposure limits（OEL）Usually below 1mg/m3, or there is no publicly available credible exposure limit. Enterprises need to establish channels and methods for obtaining drug or intermediate OEL, and adopt a drug grading management system. OEB is often divided into 5 levels:
The OEB level is also the basis for selecting control measures, which should take into account both the drug exposure concentration (OEL) and the exposure amount (Potency). The OEB3 level product line already requires control measures such as fume hoods.
1. What is bag in bag out?
Bag in bag out（Bag-In/Bag-Out, abbreviated asBIBO）It is a box used for air filtration and pollutant treatment in high pollution environments.It is mainly composed ofFilter unit, sealed box, inlet and outlet air ductsBag FilterReplace the device and other components.itsuniqueThe design ensures that when replacing the filter, the operator will not directly come into contact with the contaminated filter, effectively preventing the leakage of pollutants and ensuring the safety of personnel and the environment.
2. The history of bag in and bag out
Bag in bag out high-efficiency air filters appeared in the 1950s and 1960s, and are currently widely used in various high-risk or high isolation requirements fields, such as chemical and biological (CB) protection, chemical, biological, and radiological (CBR) protection, nuclear, biological, and chemical (NBC) protection, hospital isolation rooms, pharmaceutical equipment, microelectronic environments, food processing areas, biological research, genetic and biotechnology laboratories, industrial processing and emission systems, chemical processing equipment, animal disease research laboratories, radioactive isotope processing equipment, nuclear power plants, strategic nuclear facilities, D.O.E equipment, military bases, etc.
1. Anrui combines the development experience of European and American laboratories, and based on the national conditions of domestic laboratories, innovatively develops a new generation of OEB level intelligent balance weighing covers with "bag in bag out". The laboratory development trend of intelligent operation and monitoring can ensure both safety and stable readings. The weighing cover of the Anruis bag in and out intelligent balance complies with the OEB 5 standard and JG/T 385 2012 standard.
2. The "bag in bag out" box is a fully sealed box, and is used foruseuniqueHEPA lower sealing design, which can ensure that the interior of the box is not polluted, reduce the spread of hazard sources, and consider the safety during replacement. The opening of the box and the box are welded as a whole to ensure that the sealing ring and the sleeve bag will not fall off during replacement. The sealing bag in the bag and out of the bag is a special safety bag of TPU (thermoplastic polyurethane elastomer, which has high thickness, toughness, wear resistance, and aging resistance), and the opening is equipped with a tightening device and a recycling pouch for waste bags. The biggest feature of the bag in and out of the box is that the installation and replacement of the filter are carried out under the protection of a dedicated PVC bagcompletelyNot in contact with the outside air, thus ensuring the safety of personnel and the environment
5. Case sharing
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