Analysis of the efficacy and application of injection grade phospholipid excipient DSPC

We know that DSPC is a phospholipid widely used in various fields such as pharmaceutical preparations. As a pharmaceutical excipient, it often appears in the formulation of drug preparations such as liposome microbubble contrast agents, special lipid microspheres, and drug complexes. In this article, AVT editor will introduce to you the efficacy of DSPC in compound liposomes!

DSPC is a fully synthetic PC phospholipid with a purity of 99%, also known as phosphatidylcholine. DSPC with CAS number 816-94-4 is an excellent membrane material choice and has many applications in compound liposomes, such as erythromycin and irinotecan. DSPC has better stability than HSPC and can completely replace HSPC, but the price and cost are higher.

1. DaunoXome Liposome Injection (1996)

Indication: Kapoor's sarcoma associated with HIV

DSPC Usage: Dissolve with cholesterol in an appropriate organic solvent, spin evaporate in a 55 ° C water bath, vacuum film, and then perform subsequent hydration, granulation, drug loading, and other operations.

2. Irinotecan Liposome Injection (0nivyde, 2015)

Indications: Combination therapy with fluorouracil and folinic acid for the treatment of metastatic pancreatic AI

DSPC Usage: Dissolve with other phospholipid excipients in appropriate organic solvents, spin evaporate and vacuum in a 60 ° C water bath to obtain lipid films, and then perform subsequent hydration, granulation, drug loading, and other operations.