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Beijing Mancang Technology Co., Ltd
What are the main functions of simulating the digestive system in vitro?
Date: 2025-07-02Read: 2
In vitro simulated digestive system SHIME is widely used in gut microbiota laboratories and nutrition laboratories of universities, research institutes, and enterprises. It is an ideal tool for in vitro gut model SHIME experiments, including batch culture models, continuous fermentation culture systems (ascending colon, transverse colon, and descending colon), and human gut microbiota simulators (stomach, small intestine, ascending colon, transverse colon, descending colon). In vitro models used for predicting or evaluating the digestibility, bioavailability, nutrient release kinetics, and structural changes of compounds. It can be applied in food nutrition, functional active substance metabolism research, drug release kinetics research, probiotics and prebiotics, food toxicology research, animal nutrition and feed research, etc.
The main functions of the in vitro digestion simulation system for monogastric animals are:
1. Control the physical and chemical environment in the gastrointestinal tract; Peristalsis, acidity, slight positive pressure, anaerobic environment;
2. Detecting the chemical changes in "food" during the digestion process;
3. Automatically detect and control the acidity of different simulated parts;
4. Perform enzymatic hydrolysis reaction and simulate the secretion of digestive enzymes in the gastrointestinal tract;
5. Experimental repeatability deviation<1%; Absorption deviation<2%;
6. Simulate small intestine endocrine digestive enzymes to further digest and degrade substrates; At the same time, provide an environment for the growth of various microorganisms in the gastrointestinal tract of monogastric animals;
7. Simulate multiple absorption methods and perform active and passive absorption based on the absorption characteristics of different parts;
8. The secretion volume and rate of digestive and secretion fluids can be regulated within the range of 0-150ml/min; Parameters can be set and modified by oneself;
9. Control the constant temperature of the gastrointestinal tract; Temperature can be controlled between 30-40 ℃; Accuracy: ± 0.1 ℃; Intelligent PID temperature control; Adopting a brand new semiconductor waterless temperature control system;
10. The client development adopts Siemens programmable on-site control and dual monitoring and control on the upper computer end;
11. The server adopts WFC remote communication mode;
12. Easy to operate and assemble, the program can automatically analyze data and draw curves, and the system comes with multiple simulated process formulas;
13. The device adopts dual screen data synchronization display, which is intuitive and convenient;
14. Cloud based development system, which can be operated through an APP on mobile devices, as well as cloud data storage, making it convenient to use.
