In the process of water preparation in the pharmaceutical industry, Hunan Hexin Pharmaceutical Equipment Co., Ltd. has developed a two-stage reverse osmosis equipment. Through the collaborative operation of two-stage reverse osmosis membrane separation technology, it achieves deep treatment from raw water to purified water, adapts to the water needs of various drug production such as injections and oral preparations, and provides pharmaceutical enterprises with a stable water supply solution that complies with GMP standards.
1、 Equipment structure and workflow
The equipment is centered around "deep purification and stable water production" and consists of four parts: pre-treatment system, primary reverse osmosis unit, secondary reverse osmosis unit, and post-treatment system. Through multiple stages of filtration and separation, water quality improvement is achieved
1Preprocessing systemIncludes quartz sand filter, activated carbon filter, and security filter. Quartz sand filter removes large impurities such as sediment and suspended solids from raw water, reducing turbidity; Activated carbon filters adsorb residual chlorine, organic matter, and odors to prevent chlorine from oxidizing and damaging subsequent reverse osmosis membranes; The security filter (with an accuracy of 5 μ m) intercepts small particles, prevents membrane element blockage, and provides qualified inlet water for the reverse osmosis unit.
2First level reverse osmosis unitUsing roll type reverse osmosis membrane components (mostly made of aromatic polyamide), at an operating pressure of 0.8-1.2MPa, more than 98% of the salt, colloids, microorganisms, and organic matter in the raw water are intercepted, and the water production resistivity can reach 1-10 M Ω· cm, meeting the preliminary purification requirements; Equipped with high-pressure pumps, pressure sensors, and flow meters, real-time monitoring of operating status to ensure stable water production.
3Secondary reverse osmosis unitUsing the first stage reverse osmosis produced water as the inlet to further improve purification accuracy. By optimizing the arrangement of membrane elements and operating pressure (0.6-1.0MPa), residual trace salts and impurities are retained, and the water production resistivity is stable at 10-15M Ω· cm or above, which meets the quality standards for purified water in the Chinese Pharmacopoeia; Set up a circulation pipeline within the unit. When the water quality does not meet the standard, it will automatically flow back to the first level water production tank to prevent unqualified water from entering the subsequent stages.
4post-processing systemIncludes UV sterilizer and precision filter. UV sterilizer (wavelength 254nm) kills microorganisms in the produced water to prevent secondary pollution; Precision filters (with an accuracy of 0.22 μ m) intercept potential microbial corpses and small particles, ultimately ensuring stable and reliable effluent quality.
2、 Core technical characteristics
•Water quality assurance designTwo stage reverse osmosis membranes operate in series, equipped with online conductivity meters and TOC detectors, to monitor the quality of the produced water in real time. The data can be synchronously uploaded to the control system. When the indicators exceed the set range, the equipment automatically alarms and starts the protection program; The membrane components are standardized in size, easy to replace, and compatible with different brands of membrane components, reducing subsequent maintenance costs.
•Energy saving and stable operationThe high-pressure pump adopts frequency conversion control technology, which automatically adjusts the speed according to the inlet pressure and production water demand, saving 15% -20% energy compared to fixed frequency pumps; The system is equipped with an automatic flushing function, which performs low-pressure flushing on the membrane components before shutdown to remove residual impurities on the surface and extend the service life of the membrane (under normal operating conditions, the service life of the membrane components can reach 2-3 years).
•Operation and ComplianceEquipped with PLC control system and touch screen, it can set parameters such as inlet flow rate, operating pressure, flushing cycle, etc., and supports manual and automatic operation modes; The main body of the equipment is made of 304 stainless steel material, and the pipeline welding complies with GMP standards. The inner surface is polished (roughness Ra ≤ 0.8 μ m), with no hygiene dead corners, making it easy to clean and verify; Equipped with complete operation data recording function, it can trace historical operations and water quality data, meeting the compliance requirements of the pharmaceutical industry.
•AdaptableThe pre-treatment system configuration can be adjusted according to the quality of the raw water (such as municipal tap water and groundwater). For example, when the hardness of the raw water is high, a softener can be added to remove calcium and magnesium ions and avoid membrane element scaling; The water production flow rate can be designed to be 0.5-50m ³/h according to demand, suitable for the water needs of pharmaceutical companies of different scales.
At present, Hunan Hexin Pharmaceutical's secondary reverse osmosis equipment has become the preferred equipment for many pharmaceutical companies to prepare purified water. Its stable water quality output and compliant design concept provide important support for the safety and stability of drug production.