Jinan Dawei Machinery Co., Ltd Mu Ziqi

The definition of cell level ultrafine grinding and cell level ultrafine powder traditional Chinese medicine: The grinding operation aimed at breaking the cells of traditional Chinese medicine is called cell level ultrafine grinding. The traditional Chinese medicine powder obtained through cellular level ultrafine grinding operation is called cellular level traditional Chinese medicine micro powder, and the traditional Chinese medicine made based on cellular level traditional Chinese medicine micro powder is called cellular level ultrafine powder traditional Chinese medicine, abbreviated as ultrafine powder traditional Chinese medicine.

The functions and characteristics of traditional Chinese medicine cell level ultrafine grinding and cell level ultrafine powder:

1、Improve bioavailability. Any crushing operation can crush the cells of traditional Chinese medicine to a certain extent, but the rough crushing operation has a low cell wall breaking rate. The larger the particle size of the powder, the lower the cell wall breaking rate.

After the cell breaks through the wall, the contents of the broken cell can directly contact the solvent, and its active ingredients can all enter the solvent and be absorbed by the human body. However, in general crushed particles and decoction pieces, most cells are intact, and their particles are composed of several, dozens, or even more cells. The effective medicinal ingredients in cells need to pass through several or even dozens of cell walls before they can enter the solvent and be absorbed by the human body. Moreover, a considerable portion of cellular components cannot penetrate the cell wall and enter the solvent, so this part can only be thrown away for nothing. Therefore, the effective ingredient release amount and release speed of cell level ultrafine powder traditional Chinese medicine, as well as the amount of drug effective ingredient absorbed by the human body per unit time, will be higher than that obtained by ordinary crushing methods. The types of drug effective ingredients released will also be more diverse than those obtained by ordinary crushing methods, and the effective time of the drug will be significantly shortened. The drug will have a more comprehensive and stronger effect on the human body.

After entering the human body, drugs first need to undergo the action of beneficial bacteria in the body. Due to the small size of cell level ultrafine particles of traditional Chinese medicine, the effect of beneficial bacteria will be more rapid and strong. The amount and concentration of products produced by the action of bacteria will be significantly increased, which is also beneficial for human absorption and enhances absorption intensity.

After ultrafine grinding, the cell debris particles of traditional Chinese medicine become smaller, which enhances its adhesion to the intestinal wall. The residence time of traditional Chinese medicine particles in the intestine increases, which is beneficial for drug absorption.

Based on the above, it can be expected that the direct consumption of cell level ultrafine crushed traditional Chinese medicine will significantly enhance the comprehensive absorption of ingredients by the human body, increase the absorption intensity, and increase the absorption amount, thereby significantly improving the bioavailability.

2、Homogenization in compound grinding. Most traditional Chinese medicines are compound formulas, which are composed of various medicinal herbs. After the cell wall breaks, the water and oil inside the cell migrate out, making the surface of the particles appear semi moist. Stable particle clusters (also known as microparticles) are formed between particles, and each particle cluster contains the same proportion of traditional Chinese medicine ingredients. The physical structure of the particle cluster varies with different combinations and interactions of HLB values (hydrophilic, lipophilic equilibrium values), ductility, fragmentation, water (oil) content, specific gravity, and other components in the composition. This structure will homogenize the effective ingredients of traditional Chinese medicine, allowing them to be evenly absorbed by the human body, which can also enhance the effectiveness of the drug.

3、Improve the industrial extraction rate of active ingredients. Due to the high cell wall breaking rate and reduced dissolution resistance, the use of cell level ultrafine powder in the traditional Chinese medicine industry for extracting active ingredients can significantly improve the extraction rate.

4、Reduce the sensation of oral granules. Research on chocolate shows that the average particle size of the material is around 25um, and most of the particles have a particle size between 15-20um. It has a very smooth and delicate taste when eaten, and when the average particle size exceeds 40um, it can clearly feel rough. The average particle size of traditional Chinese medicine compound after cell level ultrafine grinding operation is generally below 20um, with more than 75% of the particles being finer than 20um. Its particle size is lower than the threshold for oral particle sensation, so there is no roughness when taking it.

5、Additional effects. Since it is a cellular level ultrafine pulverization, insect eggs that are comparable in size to cells will also be killed. Thus reducing the threat of pests to traditional Chinese medicine.

Ultra fine grinding is the basis for improving the efficacy of pharmaceuticals, and Western medicine ultra fine grinding can enhance efficacy and reduce dosage. The same goes for traditional Chinese medicine. After cell level ultrafine grinding, cell wall breaking significantly improves the efficacy of the medicine. Therefore, choosing a reasonable ultrafine grinding equipment is very important for ultrafine grinding of traditional Chinese medicine. In the following article, we will focus on introducing the relevant technologies of the Dawei cell level ultrafine pulverizer developed and produced by Jinan Dawei Machinery Co., Ltd., as well as its application in the ultrafine pulverization of traditional Chinese medicine.