Jinan Dawei Machinery Co., Ltd. is a new technology enterprise specializing in the research and development, design, production, and sales of advanced cellular level ultrafine grinding equipment.
The company specializes in micro (nano) Rice noodles technology, process, equipment and technical services, and undertakes the research of related topics of the Chinese medicine pharmaceutical powder engineering department. The vibrating ultrafine crusher was successfully developed in 1996, and technical engineers from the company's R&D department participated in the design and development of the vibrating ultrafine crusher. Until now, we have been committed to the research and development, design, updating and improvement of ultrafine grinding equipment and cell wall breaking equipment. From the single XDW-6 series and XDW-F (L) 100 series models and specifications, it has developed into the current XDW-2 series, XDW-6 series, XDW-9 series, XDW-15 series, XDW-30, XDW-40 series, XDW-70 series, XDW-F100 series, XDW-Z100 series, XDW-L100 series, XDW-L200 series, XDW-L400 series and other models and specifications for users to choose from. From the original pharmaceutical grade stainless steel material, a new ceramic series equipment with zero metal mixing has been developed to meet the requirements of customers' products; Known as "green ultrafine grinding equipment and technology".
Ceramic materials have the following characteristics: 1. Adopting wear-resistant structural ceramic materials, their performance is far superior to agate, with high crushing efficiency, low wear, and long service life.
2. Structural ceramics have inertness and no sediment residue in living organisms.
3. Zero metal mixed with non polluting materials can be used for the production of injections or the preparation of nanomaterials.
And it has formed a more suitable crushing equipment that can be customized according to the actual problems and needs of users. Adhering to the business philosophy of "becoming stronger, bigger and longer, and creating value for customers", after years of development, the company has now become a domestic professional engaged in the integration of micro (nano) Rice noodles body technology, cell wall breaking technology, process, equipment and technical services.
The company combines ultrafine powder technology with traditional Chinese medicine and has conducted research on the characteristics and particle size properties of over 2000 types of Chinese medicinal materials. After tens of thousands of ultrafine grinding and cell wall breaking (membrane) experiments, the concept of "Chinese medicine cell level ultrafine grinding, full component drug delivery, micronized Chinese medicine, and Chinese medicine cell wall breaking decoction pieces" has been proposed both domestically and internationally. We have accumulated a wealth of successful practical experience in achieving traditional Chinese medicine cell level ultrafine grinding operations with the main goal of cell wall breaking.
The company will continue to provide pre-sales technical services such as technical consultation, process testing, equipment selection and design for customers in different industries, and develop, design, and produce more suitable ultrafine grinding and cell wall breaking equipment for customers, in order to meet their actual needs to the maximum extent and create greater value for them.
This device belongs to the fourth generation vibration mill and has the characteristics of high crushing efficiency, high wall breaking rate, low crushing temperature (temperature controllable), crushing, no residue residue, fully enclosed operation, and low material loss. The particle size of the powder can reach 1-0.1 μ m, and the cell wall (membrane) breaking rate is over 98%. Nowadays, Dawei ultrafine grinding and cell wall breaking technology have been widely used in industries related to powder applications, such as pharmaceuticals (including veterinary drugs and pesticides), food (food), cosmetics, chemical building materials, metallurgical energy, electronic environmental protection, and resources, and have gained a wide range of users' recognition and reputation.
At present, the company produces cell wall breaking and ultrafine grinding equipment such as XDW-2 series, XDW-6 series, XDW-9, XDW-15, XDW-30, XDW-40, XDW-70, XDW-F100 series, XDW-Z100, XDW-L100, XDW-L200 series, XDW-L400 series, etc; XDW-C160S, XDW-C260S, XDW-C300S, XDW-C360S, XDW-C520S, XDW-C680S and other coarse crushing (corner type strong crushing) equipment; There are nearly a hundred equipment models available for customers to choose from, including universal crushers such as XDW-20A, XDW-30B, XDW-40B, XDW-60B, as well as small high-speed crushers.
Jinan Dawei Machinery Co., Ltd. will provide equipment with advanced technology, high quality, stable performance, and an annual failure rate of almost zero; With worry free after-sales service and a more favorable price system, we sincerely cooperate with our customers and work together to create brilliance!
The company's mission is to create value for customers. Company commitment: to provide customers with high-quality mechanical products and auxiliary equipment; To provide customers with timely, accurate, and effective after-sales service, thereby providing great guarantee for creating value for customers. Quality is the foundation of enterprise survival, and service is the guarantee of enterprise survival. Welcome customers to cooperate, collaborate, benefit from each other, and develop and progress together with us.

Dawei Machinery - Cell level Ultra fine Grinding
The pulverization operation that improves the bioavailability of traditional Chinese medicine by breaking the cell wall (membrane) of animal (plant) medicinal materials is called traditional Chinese medicine cell level micro pulverization. The vast majority of traditional Chinese medicine varieties come from animals (plants). Animal (plant) medicinal materials are composed of cells with multiple functions, including cell wall, cell membrane, cytoplasm, nucleus, etc. The particle size is generally between 10 μ m and 100 μ m, and the medicinal active ingredients mainly exist in the cytoplasm and nucleus. In the intact and undamaged state of cells, effective ingredients can only be utilized after being released through the cell membrane and cell wall. The complete cell membrane and cell wall form resistance to the release of active ingredients, and this resistance increases sharply with the increase of the number of cells in the cell mass. The medicinal active ingredients mainly exist within the cell - between the cytoplasm and the nucleus. Due to the dual effects of the inward resistance of the cell wall (membrane) and the coagulation resistance of cell aggregates (coarse powder), the active ingredients are difficult to release and be absorbed by the body or intestines, which is an important reason for the large and unclear dosage of traditional Chinese medicine. To eliminate this resistance, a micro crushing process should be adopted to break down the cells so that the active ingredients inside the cells can directly contact the solvent. This type of homework is not aimed at fineness, and fineness is only used as a macroscopic detection method, which cannot express the actual fineness of medicinal powder. Generally speaking, the higher the cell wall breaking rate, the finer its fineness. After breaking through the cell wall, the active ingredients inside the cell are fully exposed (instead of being released through the cell wall [membrane] as before), making the drug more effective. After the drug particles were finely ground at the cellular level, a small amount of intact cells were observed under electron microscopy.

working principle
The Dawei Mechanical Ultra fine Grinding Equipment belongs to the new fourth generation vibration mill. It adopts multiple advanced technologies and applies high-speed impact force and shear force according to the different characteristics of the material, so that the material is subjected to high acceleration impact, friction, compression, cutting and other effects of the medium in the grinding cylinder, and can achieve ideal grinding effect in a short time. The material becomes fluidized during the crushing process, so that each particle has the same stress state, achieving precise mixing (dispersion) effect while crushing. By adjusting parameters such as acceleration, it is possible to achieve operations with the goal of crushing and grinding or precision mixing (blending) as the main objective.
The device adopts the working principle of vibration crushing, filling the grinding medium such as hard material balls, rods or columns in the grinding cylinder (crushing chamber). The grinding cylinder produces circular vibration in the clockwise and counterclockwise directions as shown in Figure 1 under the action of external excitation force. The strong vibration of the grinding cylinder causes the medium inside the grinding cylinder to undergo a throwing motion. Under the action of this throwing motion, each medium produces a rotation in the same direction as the circular vibration. At the same time, the medium group also produces 3-5 low-frequency rotations opposite to the circular vibration. So the medium sometimes disperses and sometimes collides with each other, producing a positive impact force p and a lateral shear force L on the material as shown in Figure 2. The material is finely ground, broken, and crushed under the impact, compression, and shear forces of P and L.

The Dawei ultrafine crusher adopts the following advanced technologies

1. Fully enclosed non graded technology: The fully enclosed multi grinding non screening technology used to preserve the active ingredients effectively avoids phenomena such as segregation and loss of active ingredients, and environmental pollution caused by dust spillage.
2. Compression micro crushing technology: In order to improve the crushing efficiency and effectiveness, high-speed impact force and shear force are used to subject the material to the squeezing, kneading, and tearing effects of the medium in the grinding cylinder, shorten the crushing time, and improve the crushing efficiency; At the same time, due to the fluidized state of the material and the same stress state of each particle, its own viscous effect can form uniformly dispersed and precisely composite particle clusters in the finished product, increase density and improve bioavailability, and enhance micro crushing efficiency and technology.
3. Dynamic optimization technology: a technology that optimizes and adapts according to the different characteristics of materials while ensuring the improvement of micro crushing efficiency and effectiveness.
4. Mechatronics technology: a technology that achieves high performance and level of equipment, reduces manual labor, ensures stable and controllable product quality, and avoids quality instability and pollution caused by excessive manual intervention.
5. Comprehensive automation technology: equipped with single machine multifunctional automation (FMC flexibility), making small-scale drug production as simple as large-scale assembly line production.
6. Purification technology: The Dawei ultrafine grinder series is designed and manufactured strictly in accordance with GMP standards, which can meet the special requirements of pharmaceutical powder equipment.

The Dawei ultrafine grinding series equipment has the following characteristics

The parts in contact with the material are all polished stainless steel, which is a universal material for medical and food machinery (can also be changed to other metal materials according to user requirements), to avoid the mixing of heavy metals such as arsenic, cadmium, mercury, lead, copper, etc.
2. Cleanliness and hygiene: Smooth inner and outer surfaces, versatile use of one machine, reduced pollution, and reduced cleaning workload; The crushing process is fully enclosed without dust spillage, fully improving the working environment, and effective ingredients are not lost.
3. Adopting a composite (transparent) soundproof cover greatly reduces noise.
4. Easy to disassemble (assemble), easy to clean, and easy to change materials. Can be cleaned and disinfected with water, compressed air, alcohol, steam, etc.
5. Easy to operate: Capacity adaptation, ensuring material discharge, easy operation and material replacement.
6. Easy maintenance: compact structure, small footprint, and convenient maintenance.
7. Improving the environment: Fully enclosed operations with dust spillage, no loss of active ingredients, and no generation of drug residues can improve the working environment.
8. Efficiency: Crushing, no residue left. The bidirectional effect of high-speed impact force and shear force shortens the crushing time and improves the crushing efficiency.
9. Broad spectrum adaptation: Suitable for any fibrous, high toughness, high hardness, or moisture content material. Materials that require breaking of cell walls, such as pollen and other spore materials, have a breaking rate of over 98%. Adapt to both dry and wet crushing simultaneously. Water, alcohol, or other liquids can be added during wet crushing.
10. Temperature controllable: Through configuration, micro crushing can be carried out at high temperature, room temperature, and low temperature, which can maintain the original physicochemical properties and active ingredients of the material. Inject cold water into the jacket on the outer wall of the grinding cylinder. The crushing temperature can be controlled by adjusting the temperature and flow rate of the cooling water. Low temperature crushing, the freezing system can reach a low temperature of minus 35 ℃ (low-temperature configuration).

The Dawei ultrafine grinding equipment has the following advantages

1. Improving product quality: Through cell level micro grinding, the active ingredients are fully released, resulting in high bioavailability; Under the premise of ensuring, the dosage can be reduced; The quality of the finished product is stable and controllable.
2. Improving the grade of finished products: By using cell level micro grinding, combined with surface modification, particle design, composite or precision coating and other application technologies, it provides an effective means for the reform of traditional Chinese medicine dosage forms towards miniaturization and diversification.
3. Reduce production costs: By using cell level micro pulverization, drug efficacy can be improved (reducing dosage), production processes can be simplified (reducing labor and equipment investment), and the requirements for reducing production costs can be achieved.
4. Increase sales of finished products: Due to the stable and controllable quality of finished products, their small size, high grade, large profit margin, and market competitiveness, sales will increase.
5. High added value of finished products: By improving the quality of finished products, reducing costs, and increasing sales, the finished products have market competitiveness and high added value, effectively reducing the investment risk of Dahua Micro mechanical cell level micro crushing technology, processes, and equipment, and greatly shortening the investment payback period.

Application of Dawei ultrafine grinding equipment

In addition to being applied in biopharmaceuticals, food, and cosmetics, it is also widely used in various industries related to powder applications, such as building materials (preparation of water slag, fly ash, etc.), chemical industry, metallurgy, environmental protection (brick making from garbage micro powder, etc.), electronics (paddle materials, graphite emulsion, etc.), etc.

Comparison of performance between Dawei ultrafine pulverizer and other traditional Chinese medicine pulverization equipment

The ultrafine grinding of traditional Chinese medicine currently mainly refers to cell level micro grinding. The main active ingredients of active drugs are usually distributed within cells and intercellular matrix, with the intracellular component being the main one. When the cell breaks through the wall, the active ingredients inside the cell are exposed, so the efficacy is greatly improved and the onset speed is fast. At present, domestic development includes technologies and equipment such as ball mills, planetary mills, rotor crushers, airflow crushers, and vibration crushers.
The ball mill has a wide range of material adaptability, low cost, easy operation and maintenance, and good equipment reliability. However, the equipment efficiency is too low and cannot handle the processing of high toughness and fibrous material powders.
Although planetary mills have high production efficiency, their single machine capacity is too small and inconvenient to use, so they are not widely used. Currently, both Germany and Japan use vibration mills for ultrafine grinding of medicinal materials. But vibration mills can be divided into one, two, three, and four generations, and only the fourth generation vibration mill is an ultrafine grinding equipment. It is used for the breaking of spore structures (with a particle size of only 10 μ m) such as Ganoderma spore powder, which can be completed in a very short time with a breaking rate of up to 95%. It can be used for ultrafine grinding of any traditional Chinese medicine. Used for mineral medicine grinding up to 0.3 microns.
The research on airflow pulverizer cannot achieve D50<3 μ m. This machine is only a micro pulverization equipment, not a ultrafine pulverization equipment, and it is very difficult to pulverize fibrous and tough traditional Chinese medicine. Especially during the crushing operation, there is a relatively high-speed airflow that carries away the volatile components of the medicine, causing loss of efficacy. Therefore, this machine is suitable for the micro crushing of brittle chemicals or mineral Chinese medicine, and is not suitable for the ultrafine crushing of dynamic Chinese medicine.
Multiple types of sieve rotor crushers have material heads, which cannot guarantee the full component into medicine. They must not be used for micro grinding of traditional Chinese medicine, especially for the grinding of compound traditional Chinese medicine. It is suitable for crushing operations in the chemical industry.
Choosing appropriate crushing equipment is crucial for the ultrafine grinding of traditional Chinese medicine.
Process Application

The process application centered on micro mechanical cell level micro grinding technology provides a broad operational space for innovation in traditional Chinese medicine pharmaceutical technology.
1. Solved various problems in traditional Chinese medicine crushing operations
Strong fibrous (such as Ganoderma lucidum, licorice, etc.), high sugar and high viscosity (such as goji berries, Ophiopogon japonicus, etc.)
Resin based materials (such as frankincense, myrrh, etc.) have strong toughness (such as seahorses, etc.)
Animals (such as scorpions, leeches, etc.) and minerals (such as *, cinnabar, etc.)
2. Reform of traditional Chinese medicine dosage forms, reduction of dosage, and improvement of micro powder technology level
Reduce medication dosage by 80% -90% and reform traditional Chinese medicine decoction (Tiaoxin Tiaowei Tang)
New Chinese medicine micro powder decoction pieces 300 mesh
Raw powder soft capsule preparation (ginseng soft capsule)
One step preparation of ointment (Liuwei Dihuang soft capsules)
Realize granulation and compression without or with minimal auxiliary materials
(Small equipment: * 25Kg per hour)
For the purpose of reducing dosage and improving (Bawei Dihuang Pill)
Reduce the consumption of medicinal herbs (raspberry reduces losses by 20%)
Spray preparation transdermal (membrane) preparation
Realize composite and precision coating with uniformity better than ± 1 ‰ (artificial bezoar)
Low temperature quality crushing, fresh Chinese herbal medicine and fresh animal tissue (such as black chicken, crab, etc.)
The following are some examples of crushing:
Raw material particle size processing time, product particle size processing capacity, applicable models
Silk filament 15 minutes -200 mesh 96% 5Kg/h XDW-F100
Ganoderma lucidum -1mm dry 15 minutes -200 mesh 95% 15Kg/h
Pearl -2mm dry 15 minutes -300 mesh 50Kg/h
-2mm dry 15 minutes -200 mesh 15Kg/h
Scorpion, centipede, leech -2mm dry for 5 minutes -200 mesh 98% 30Kg/h
Pueraria lobata -2mm dry for 14 minutes -200 mesh 95% 30Kg/h
Dry hay -1mm dry for 12 minutes -200 mesh 30Kg/h
Bazhen Wan -10 mesh dry 25 minutes -300 mesh 98% 30Kg/h
Guifu Dihuang -10 mesh dry 12 minutes -300 mesh 97% 35Kg/h
Ganoderma spore powder, spore dry for 25 minutes, wall breaking rate ≥ 95% 10Kg/h
Aluminum powder -30mm wet for 15 minutes -10 μ m 90% 110Kg/h
Shark cartilage -5mm dry 12 minutes -200 mesh 97.5% 1.6Kg/h XDW-6
*-5mm dry for 5 minutes, 3 μ m, 24Kg/h
Antlers -1mm dry for 15 minutes -150 mesh 1.35Kg/h
Nimodipine 2mm dry 2.5 minutes -3 μ m 90% 17Kg/h
Garlic -1mm wet (soybean oil) 5 minutes -400 mesh 95% 9.6Kg/h
Tianmendong -10 mesh dry (low temperature) 15 minutes -200 mesh 95% 1Kg/h
Frankincense -2mm dry for 12 minutes -200 mesh 95% 1.25 Kg/h

Provide high-quality vibration based ultrafine grinding equipment
Using advanced technology and equipment - creating value for customers
Undertake research experiments on ultrafine grinding (processing of incoming materials)

Provide high-quality vibration based ultrafine grinding equipment

Using advanced technology and equipment-Create value for customers

Undertaking scientific research experiments on ultrafine grinding（processing with supplied materials）