Nano traditional Chinese medicine can improve the quality and level of traditional Chinese medicine, but it may affect the stability of the drug and increase the difficulty of storage in the shelf life machine,

*Nano is a unit of measurement, which is 1 nanometer per 1 million micrometers. Nano traditional Chinese medicine refers to the use of nanotechnology to manufacture effective ingredients, active parts, raw materials, and compound preparations of traditional Chinese medicine with particle sizes less than 100 nanometers. Previous studies have shown that nanoscale treatment of certain mineral drugs can lead to the emergence of new pharmacological properties. Nano traditional Chinese medicine can not only improve the bioavailability of drugs and enhance clinical efficacy, but also be convenient to carry and save drug sources. Compared with micro sized traditional Chinese medicine, the biggest feature of nano sized traditional Chinese medicine is that it cannot change the pharmaceutical properties of traditional Chinese medicine.

It must be acknowledged that nano traditional Chinese medicine is of great significance in improving the quality and level of traditional Chinese medicine. However, nano traditional Chinese medicine is far from it. Firstly, the components of traditional Chinese medicine are very complex and the mechanism is unclear. Nanotechnology treatment can correct some of the original defects of traditional Chinese medicine and enhance its efficacy through the modification of nano particles, but it may also have the opposite effect. If nano treated, it may double the A effect of traditional Chinese medicine, significantly weaken the B effect, and produce C and D effects that were not originally present. In terms of toxic side effects, similar changes may also occur, and the uncertainty of the effective ingredients and pharmacodynamics of traditional Chinese medicine after nanotechnology will pose a hidden danger to the stability and controllability of drug quality. Secondly, the scope of nano traditional Chinese medicine should be limited. If it is restricted to certain mineral medicines containing low molecular weight, inorganic molecules, or insoluble substances, it has important practical value; But if the scope of nanotechnology is extended to include even traditional Chinese medicine decoction pieces, caution should be taken not to damage the active ingredients of the drug in order to obtain nanoparticles. Each traditional Chinese medicine decoction piece is like a warehouse containing numerous compounds, and people are still unclear about its active and non active ingredients. Hastily nanotreating it may not be worth the loss. At the same time, the current cost of preparing nanoparticles is too high, and traditional Chinese medicine, which was originally known for its high quality and low price, will lose its price advantage after undergoing nanoscale treatment. Therefore, even if nano traditional Chinese medicine is technically mature, it may still be difficult to promote due to price factors. The latter issue is that nano traditional Chinese medicine, due to its ultrafine particle size, may affect the stability of the drug and increase the difficulty of shelf life and storage.

Although there is a special preference for nanomedicine in China, there is no trend to apply nanotechnology to all drugs. Instead, it is mainly used to modify certain insoluble drugs or protect certain special active drugs. The former aims to improve and enhance bioavailability, such as nano calcium. The latter mainly controls the release of drugs and prolongs the duration of drug action, such as oral active peptides.

Micro sized traditional Chinese medicine can increase the bioavailability of drugs and accelerate their onset time.

The concept of micro sized traditional Chinese medicine is proposed with the aim of exploring its application in the modernization of traditional Chinese medicine and making it an acceptable drug in society.

Micro sized traditional Chinese medicine refers to a new type of Chinese medicine with a particle size of micrometers that can maintain the inherent pharmacological substance basis of traditional Chinese medicine. Micro sized traditional Chinese medicine includes micro sized medicinal herbs, micro sized extracts of traditional Chinese medicine, and micro sized preparations of traditional Chinese medicine. Introducing micro technology into the field of traditional Chinese medicine manufacturing can change the "coarse, black, and large" appearance of traditional Chinese medicine, making it a modern Chinese medicine with controllable quality and temperature, reliable efficacy, and excellent formulation.

1 micrometer is 1000 times larger than 1 nanometer, equivalent to 1/60th the diameter of a human hair. Why can micrometers maintain the inherent therapeutic effect of traditional Chinese medicine, while nanomaterials change the original medicinal properties of traditional Chinese medicine? The particle size of micron sized traditional Chinese medicine is generally in the range of 1-75 microns, with an average particle size of about 15 microns. According to the principles of physics, the pharmacological substance basis of traditional Chinese medicine particles within this range will not undergo significant changes compared to the original ordinary Chinese medicine decoction pieces or preparations, nor will it affect the properties, pharmacological characteristics, and functional indications of traditional Chinese medicine. Traditional Chinese medicine at the micrometer level only involves ultrafine particle size, and its degree of refinement does not involve changes in atomic or molecular structure. Therefore, it will not damage the effective ingredients of the drug, nor will it pose a threat to safe medication.

The biggest advantage of micrometer sized traditional Chinese medicine is that it greatly improves the absorption and bioavailability of drugs. From a pharmacological perspective, the dissolution rate of drugs is positively correlated with the specific surface area of the drug particles, while the specific surface area is inversely proportional to the particle size. Therefore, the finer the particle size of the drug, the larger its specific surface area, which is more conducive to the dissolution of the active ingredients of the drug. Micro sized traditional Chinese medicine achieves the level of ultrafine powder through its particles, significantly increasing its specific surface area and solubility of active ingredients in the gastrointestinal tract, thereby increasing the bioavailability of the drug and accelerating its onset time. In addition to oral administration, traditional treatment methods such as local application of traditional Chinese medicine, acupoint administration, and scalp absorption will also generate new therapeutic effects and exert new therapeutic effects with the improvement of the bioavailability of micro Chinese medicine. In addition, micron TCM and related technologies will also promote the diversification of TCM dosage forms, accelerate the development of new dosage forms such as buccal tablets, tongue instant tablets, dry powder absorbents, sprays, etc., to meet the needs of different patients.

China is a traditional medicine powerhouse, but not a traditional medicine powerhouse. The widespread application of micro sized traditional Chinese medicine and related technologies will rapidly and comprehensively improve the technological level of China's traditional Chinese medicine industry, enhance the quality and efficacy of traditional Chinese medicine, and strengthen its competitiveness in the market. Compared with nano traditional Chinese medicine, the cost and price of micro traditional Chinese medicine are greatly reduced, making it more advantageous and widely applicable in the current field.

It is understood that micro scale traditional Chinese medicine is no longer just a talk on paper. With the improvement of ultrafine grinding technology, cell wall breaking technology, and the emergence of ultrafine grinding equipment and cell wall breaking equipment, micro scale traditional Chinese medicine and cell level traditional Chinese medicine have been widely used in the traditional Chinese medicine industry.

Jinan Dawei Machinery Co., Ltd. is a professional enterprise that designs, produces, and sells advanced level equipment for cell level ultrafine grinding.

The ultrafine grinding equipment produced by it is based on cell wall breaking and belongs to the fourth generation vibration mill, which has the characteristics of high grinding efficiency, high wall breaking rate, low grinding temperature, and fully enclosed operation. The particle size of the powder can reach 1-0.1 μ m, and the cell wall breaking (membrane) rate is over 95%. Its application range covers industries such as pharmaceuticals (including veterinary drugs and pesticides), health food, cosmetics, chemical building materials, metallurgical energy, electronic environmental protection, etc., and has been widely used.

At present, the company produces nearly 20 equipment models for customers to choose from, including XDW-6 series, XDW-9, XDW-15, XDW-F100 series, XDW-L100 series, etc.

The cell level ultrafine grinding equipment is a grinding operation called traditional Chinese medicine cell level micro grinding, which improves the bioavailability by breaking the cell wall (membrane) of animal (plant) medicinal materials. The vast majority of traditional Chinese medicine varieties come from animals (plants). Animal (plant) medicinal materials are composed of cells with multiple functions, including cell wall, cell membrane, cytoplasm, nucleus, etc. The particle size is generally between 10 μ m and 100 μ m, and the medicinal active ingredients mainly exist in the cytoplasm and nucleus. In the intact and undamaged state of cells, effective ingredients can only be utilized after being released through the cell membrane and cell wall. The complete cell membrane and cell wall form resistance to the release of active ingredients, and this resistance increases sharply with the increase of the number of cells in the cell mass. The medicinal active ingredients mainly exist within the cell - between the cytoplasm and the nucleus. Due to the dual effects of the inward resistance of the cell wall (membrane) and the coagulation resistance of cell aggregates (coarse powder), the active ingredients are difficult to release and be absorbed by the body or intestines. This is an important reason for the high dosage and unclear therapeutic effect of traditional Chinese medicine. To eliminate this resistance, a micro crushing process should be adopted to break down the cells so that the active ingredients inside the cells can directly contact the solvent. This type of homework is not aimed at fineness, and fineness is only used as a macroscopic detection method, which cannot express the true situation of medicinal powder. Generally speaking, the higher the cell wall breaking rate, the finer its fineness. After breaking through the cell wall, the active ingredients inside the cell are fully exposed (instead of being released through the cell wall [membrane] as before), making the drug more effective and rapid. After the drug particles were finely ground at the cellular level, only a very small amount of intact cells were observed under electron microscopy.

With the application of cell wall breaking based ultrafine grinding equipment developed and produced by these domestic enterprises in industries such as medicine and health food, the preparation methods of traditional Chinese medicine materials, micro extracts of traditional Chinese medicine, and cell wall breaking products have been registered. This is China's own intellectual property and also the first pioneering use of micro technology in traditional Chinese medicine research.