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nanowetech@163.com
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13928824355
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Nano Micro (Guangzhou) Instrument Technology Co., Ltd
Process principle of two channel rapid nanomedicine preparation system
Date: 2025-09-19Read: 8
The process principle of the two channel rapid nanomedicine preparation system is mainly based on microfluidic technology, which achieves efficient synthesis of nanomedicine through precise control of fluid mixing. The core process includes the following key steps:
1. Biphasic fluid input
The system loads the aqueous phase (containing active drugs) and the organic phase (containing nanocarrier precursors such as lipids) into two separate syringes, which are pumped into independent channels of the microfluidic chip.
2. Laminar mixing control
In micrometer level channels, two-phase fluids maintain incomplete mixing in laminar flow, and controllable uniform mixing is achieved through chip designed microstructures (such as 100 μ m channels), avoiding the problem of uneven particle size distribution in traditional high-pressure homogenization methods.
3. Self assembly of nanoparticles
During the mixing process, carrier materials (such as lipids) self assemble with drug molecules to form 10-1000nm nanoparticles. This process has mild conditions and high reproducibility, making it suitable for sensitive drugs such as nucleic acids and peptides.
4. Accurate parameter control
The system supports flow rate adjustment of 0.1-120ml/min, combined with a chip design with a pressure resistance of 10bar, which can optimize mixing efficiency and particle morphology, significantly reducing batch differences.
This technology has the advantages of faster preparation speed (0.5-20ml per run) and compatibility with multiple solvents (ethanol, DMSO, etc.) compared to traditional methods such as nanoprecipitation, and is particularly suitable for the production of drugs such as mRNA vaccines that require high uniformity.
