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Shanghai Shengguan Machinery Equipment Co., Ltd
Technological innovation and industry application of Shanghai Shengguan infusion filling production line
Date: 2025-07-18Read: 8
Technological innovation and industry application of Shanghai Shengguan infusion filling production line
1、 Core architecture and process flow of production line
The SGGSZ-4/8 large infusion bottle filling production line of Shanghai Shengguan adopts modular design, integrating bottle supply machine, drum type bottle washing machine, sterilization dryer, filling and capping machine, and disc positioning capping machine to achieve full process automation from cleaning to filling and capping. Its core advantages are reflected in:
Full process aseptic control: The main structure of 304 stainless steel material is matched with 316L stainless steel filling components, which complies with the new GMP standards. The bottle breakage rate is lower than the industry average, and the finished product qualification rate is ≥ 98%.
Flexible production capacity: Suitable for various specifications of infusion bottles ranging from 30-500ml, with a production capacity covering 40-100 bottles/minute, and a filling accuracy controlled within ± 2%, meeting the production flexibility of different clinical needs.
2、 Key technological breakthroughs
1. High precision filling system
Adopting volumetric plunger pump quantitative filling technology, combined with servo tracking control, to ensure the consistency of liquid filling volume. In response to the characteristics of large infusion products (such as glucose and sodium chloride injection), the equipment is equipped with a real-time pH monitoring module to avoid changes in the physical and chemical properties of the infusion during the filling process.
2. Intelligent capping process
The innovative disc positioning capping mechanism is equipped with pressure adaptive adjustment function, which solves the problem of loose sealing of traditional single rolling knives. Actual test data shows that the pass rate of screw caps has increased to 99.5%, significantly reducing the risk of liquid leakage in clinical use.
3. Energy saving and space optimization
The total length of the production line is 13.5 meters, which is 20% shorter than similar equipment, and the factory space is reduced through integrated design. The sterilization and drying process adopts hot air circulation technology, which reduces energy consumption by 15% compared to traditional modes.
3、 Industry adaptation and future trends
With the transformation of the infusion industry towards soft plastic packaging (non PVC soft bags account for 40%), Shanghai Shengguan is compatible with soft bag filling needs through expandable design. The new generation production line launched in 2025 has achieved:
Data interconnection: Real time collection of parameters such as filling volume and sterilization temperature through MES system docking, in compliance with FDA 21 CFR Part 11 electronic record specifications.
Customized services: flexibly configure equipment modules according to customer process requirements, such as adding automatic sampling stations or online labeling machines, to form a closed-loop production system.
4、 Conclusion
The Shanghai Shengguan infusion filling production line is promoting the industry's transformation from scale expansion to quality upgrading through precision improvement, intelligent transformation, and flexible adaptation. Its technical solution not only meets the strict requirements of current GMP, but also reserves technical interfaces for the production of personalized medical products in the future, such as therapeutic infusion and nutritional complex preparations.