Reasonable selection of high shear homogenizers is an important way to ensure product quality and improve economic efficiency. Generally speaking, it is necessary to closely connect with production reality and choose homogenizers with good quality, high efficiency, simple structure, easy use and maintenance, small size, and light weight as much as possible. Macroscopically speaking, the main principle should be to meet the production process requirements. Firstly, a suitable homogenizer should be selected based on the properties of the medium raw materials to meet the production process requirements. Secondly, the production capacity of the high shear homogenizer should be matched with the production capacity of the preceding and succeeding processes. The following are the parts that need to be carefully considered when making a choice:
1. Minimum flow rate: The smaller the better, which can save materials. At present, the raw materials for some drugs reach several thousand yuan/gram, and users naturally hope to complete a homogenization experiment with the least amount of materials. Moreover, the experiment is a repeated process, and the larger the minimum sample size, the more materials are wasted.
2. Homogeneous pressure: It is not necessarily better to have higher pressure. For general materials, firstly, in a sense, the higher the pressure, the smaller the particle size of the material can be processed. Secondly, the higher the pressure, the more types of materials can be processed. For example, some liquid emulsions only need to be homogenized to below 100nm at 15000psi, while some drugs, foods, especially suspensions with a certain amount of solid particles in the liquid, require a pressure of at least 26.000psi to achieve nanoscale. But it cannot be ruled out that some materials may condense under high pressure.
3. Processing effect: Of course, users hope to produce materials that can reach the nanometer level, and at the same time, have a very uniform distribution at the nanometer level, rather than some particles being tens of nanometers while others are still micrometer level.
4. Cleaning and sterilization: Imported high-pressure high shear homogenizers are very convenient for cleaning and sterilization. It is recommended to consider online cleaning and sterilization.