Laboratory sterile isolatorIt is the core equipment for achieving aseptic operations in modern laboratories and the pharmaceutical industry. It constructs a closed sterile environment through physical barriers and efficient sterilization technology, ensuring that experimental samples are not contaminated by external microorganisms and protecting operators from high activity or toxic substances. Its core design integrates a sealed structure, airflow control, and vaporized hydrogen peroxide (VHP) sterilization technology, forming a complete environmental control system. It usually adopts a combination design of 316 stainless steel hard cabin body and transparent observation window, equipped with high-efficiency particulate air (HEPA) filter and independent air treatment unit inside, which can maintain positive pressure inside the cabin (30-50Pa) and prevent external pollutants from penetrating. Operators transfer samples through glove ports or airtight doors to avoid direct contact with the cabin environment.
Laboratory sterile isolatorIts structural design usually includes the following key parts:
1. Cabin body:
The cabin is the core part of a sterile isolator, which is a closed space composed of rigid and/or flexible barrier materials used to maintain the sterile state inside. Depending on the usage scenario, the cabin can be hard (such as made of stainless steel or tempered glass) or soft (such as made of transparent PVC film) to meet different application needs.
2. Efficient filtration system:
In order to ensure the purity of the air, the cabin is equipped with a high-efficiency particulate air filter (HEPA), which can remove more than 99.97% of 0.3 micron particles in the air, thereby ensuring that the quality of the cabin air meets the cleanliness standard of ISO Class 5.
3. Hydrogen peroxide steam sterilization system:
The integrated vaporized hydrogen peroxide (VHP) sterilization system is used to thoroughly disinfect the internal space and surface of the isolator, killing microorganisms by releasing gaseous hydrogen peroxide and achieving a 6-log spore killing effect.
4. Air handling system:
Including intake and exhaust systems, as well as possible temperature and humidity control devices, to ensure that the airflow pattern inside the cabin meets requirements and maintains a constant pressure level to prevent external pollutants from entering.
5. Glove operating port:
Operators conduct experimental operations through specially designed glove holes without damaging the seal. The design of these glove holes needs to consider ergonomics to improve user comfort during operation.
6. Transfer door and material entry and exit system:
Used to safely transfer items into or out of the isolator without disrupting the sterile conditions inside. This typically involves the use of Rapid Transfer Ports (RTP), steam sterilized transfer buckets, or other types of transfer mechanisms.
7. Control system:
Modern sterile isolators are usually equipped with intelligent control systems that can monitor and adjust various parameters inside the cabin in real time, such as pressure, temperature, humidity, etc., while recording data for subsequent analysis.
8. Monitoring and alarm system:
Used to monitor changes in the cabin environment. Once an abnormal situation occurs, such as pressure drop or temperature exceeding the set range, an alarm will be immediately issued to notify the operator to take action.
9. Cleaning and disinfection facilities:
The design takes into account the characteristics of easy cleaning and disinfection, such as adopting a seamless design to reduce dust accumulation points, and components that are easy to disassemble and clean.