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Methoxy PEG PU: an intelligent polymer with pH responsive and charge reversible properties
Date: 2025-12-17Read: 0

Methoxy-PEG-PU (mPEG-PU) is an AB-type amphiphilic block copolymer consisting of a hydrophilic soft segment (mPEG) and a hydrophobic/hard segment (PU). It integrates the biocompatibility of PEG with the mechanical strength and functional tunability of polyurethane, enabling pH-responsive and charge-reversible properties for intelligent drug delivery and biomedical applications

Methoxy PEG PU (mPEG PU) is a block copolymer composed of polyurethane (PU) as hydrophobic/hard segment and monomethoxypolyethylene glycol (mPEG) as hydrophilic/soft segment. It combines the biocompatibility of PEG with the mechanical properties and functional adjustability of polyurethane, making it an intelligent polymer with pH response and charge reversal characteristics.

Chinese name: pH responsive charge reversible fluorescent block polymer

English name: mPEG PU; Methoxy-PEG-PU

分子量: 0.4k,0.6k,1k,2k,3.4k,5k,10k 等(支持定制)

Supplier: Xi'an Kaixin Biotechnology Co., Ltd

Purity: ≥ 95%

Appearance: Solid powder or granules

Solubility: soluble in some organic solvents and water

Storage conditions: Freeze and dry below -20 ℃ to avoid repeated freeze-thaw cycles

Packaging specifications: 1g, 5g, 10g

Security protection:

During the operation, disposable protective clothing, masks and other protective equipment should be worn to ensure self safety.

This reagent is limited to scientific research only

Attention: When using, be sure to dry and avoid frequent dissolution and freeze-drying

Core Performance and Advantages

Intelligent responsiveness: With pH responsive and charge reversible fluorescence properties, it can change its own properties according to environmental changes (such as the slightly acidic environment of tumor tissue), achieving targeted drug release.

Excellent biocompatibility: PEG segments provide good biocompatibility, low immunogenicity, and anti protein adsorption ability, which helps to prolong the circulation time of materials in vivo.

Adjustable mechanical properties: By changing the molecular weight of PEG, the composition and proportion of polyurethane hard segments, the flexibility, elasticity, and deformation recovery ability of the material can be precisely controlled.

Microphase separation structure: Hydrophilic PEG soft segments and hydrophobic PU hard segments undergo phase separation at the microscopic level, which endows the material with unique surface properties and dynamic reconstruction ability, contributing to long-term stability.

Good processability: It has good film-forming and processability, suitable for various molding processes, and provides a foundation for functional expansion.

【 Related reagents 】

PNIPAm-b-PLA

PLA-Hyd-PEG-COOH

PLGA-COOH PLGA-COOH

mPEG-Epoxide / mPEG-Epoxide

mPEG-Aldehyde / mPEG-Aldehyde

SPDP-PEG-SPDP / SPDP-PEG-SPDP

Cyanine 7-VancomycinCy7-Vancomycin

mPEG-Fluorescein / mPEG-Fluorescein

mPEG-CH2COOtBu / mPEG-CH2COOtBu

Acid-PEG-Cy5Acid-PEG-Cy5 / Acid-PEG-Cy5

100nm Blank Liposome Control Group Liposomes

BCN-PEG-FolateBCN-PEG-Folate / BCN-PEG-Folate

BCN-PEG-cRGDBCN-PEG-cRGD / BCN-PEG-cRGD

The above content is edited and organized by YNN of Xi'an Kaixin Biotechnology Co., Ltd

This reagent is only used for scientific research experiments and cannot be used on the human body