mPEG-PAMAM， Methoxy polyethylene glycol block ethylenediamine nucleated polyamino amine (PAMAM) is a block copolymer. It combines the biocompatibility of mPEG with the high loading capacity of PAMAM, demonstrating enormous potential in the biomedical field, particularly in drug and gene delivery.

Chinese name: Methoxypolyethylene glycol branched polyamide amine

English name: mPEG PAMAM; mPEG-Dendrimer polyamidoamine； Methoxy-PEG-Dendrimer polyamidoamine

分子量： 0.4k，0.6k，1k，2k，3.4k，5k，10k 等（支持定制）

Supplier: Xi'an Kaixin Biotechnology Co., Ltd

Purity: ≥ 95%

Appearance: Solid powder or granules

Solubility: soluble in some organic solvents and water

Storage conditions: Freeze and dry below -20 ℃ to avoid repeated freeze-thaw cycles

Packaging specifications: 1g, 5g, 10g

Security protection:

During the operation, disposable protective clothing, masks and other protective equipment should be worn to ensure self safety.

This reagentonly useIn scientific research

Attention: When using, be sure to dry and avoid frequent dissolution and freeze-drying

Its synthesis usually adopts a step-by-step method:

Preparation of PAMAM core: Using ethylenediamine as the core, specific generations (such as G2, G3, G4) of PAMAM dendritic polymers are synthesized through repeated cycles of Michael addition and amidation reactions.

Modification of mPEG: The mPEG chains are connected to the surface of PAMAM through chemical coupling reactions, such as the reaction between the amino groups on the surface of PAMAM and the activated end of mPEG.

Purification and characterization: purify the product to remove unreacted substances, and use nuclear magnetic resonance (NMR), gel permeation chromatography (GPC) and other technologies for structural verification and performance evaluation

Key Properties and Advantages

High load capacity: The three-dimensional structure of PAMAM allows for a much higher load capacity than linear polymers.

Good biocompatibility and long circulation: mPEG modification can significantly reduce the inherent cytotoxicity of PAMAM and help the carrier evade immune system clearance, achieving long-lasting circulation.

Active and passive targeting: Specific recognition of diseased cells can be achieved through modification (active targeting), while its nanoscale also facilitates enrichment in tumor tissue (passive targeting).

Stimulus responsive release: The carrier can be designed to release drugs in a specific environment (such as low pH in the tumor microenvironment), achieving controlled release

【 Related reagents 】

MPEG-SS-OH

AC-PEG-Ph-CHO

CLS-PEG-SS-NHS

Mannose-PEG-RB

MPEG-SS-Hydroxyl

DSPE-PEG-Glucose

RB-PEG-Ph-CHO

RB-PEG-Ph-aldehyde

Mannose-PEG-Biotin

AC-PEG-Ph-aldehyde

DSPE-PEG-TK-COOH

Acrylate-PEG-Cyanine5

Cholesterol-PEG-SS-NHS

Mannose-PEG-Rhodamine

Phospholipids-PEG-Glucose

The above content is edited and organized by YNN of Xi'an Kaixin Biotechnology Co., Ltd

This reagent is only used for scientific research experiments and cannot be used on the human body