MPEG PLGA-OH (i.e. methoxypolyethylene glycol polylactic acid hydroxyacetic acid copolymer hydroxyl) is a block copolymer with amphiphilic properties, consisting of methoxypolyethylene glycol (mPEG), polylactic acid hydroxyacetic acid copolymer (PLGA), and a hydroxyl group (- OH) located at the end.

Among them, the mPEG segment brings excellent hydrophilicity and biocompatibility to the polymer, which can reduce its immunogenicity in the body, thereby prolonging its circulation time in the body and avoiding rapid clearance by the immune system; As a biomaterial, PLGA segment combines the dual characteristics of polylactic acid (PLA) and polyhydroxyacetic acid (PGA). Its degradation rate can be regulated by adjusting the ratio and molecular weight of PLA and PGA. The degraded products are lactic acid and acetic acid that can be metabolized by the human body; The hydroxyl groups at the end provide active sites for chemical modification of the polymer, which can react with numerous molecules containing active groups (such as carboxyl groups, isocyanate groups, etc.) to achieve functional modification, such as connecting targeted fluorescent probes or drug molecules.

Chinese name: Methoxypolyethylene glycol polylactic acid hydroxyacetic acid hydroxyl; Methoxypolyethylene glycol polylactic acid hydroxyacetic acid copolymer hydroxyl; Methoxy polyethylene glycol PLGA hydroxy

English name: mPEG-b-PLGA-OH; Methoxy-PEG-b-PLGA-OH；

Appearance: White or off white solid

Supplier: Xi'an Kaixin Biotechnology Co., Ltd

Solubility: soluble in organic solvents such as dichloromethane, chloroform, DMF, DM, etc

Purity: 95%+

Application: Surface modification of biomaterials

Structural formula:

Storage conditions: Freeze and dry below -20 ℃ to avoid repeated freeze-thaw cycles

Security protection:

During the operation, disposable protective clothing, masks and other protective equipment should be worn to ensure self safety.

This reagentonly useIn scientific research

Attention: When using, be sure to dry and avoid frequent dissolution and freeze-drying

【 Application 】

MPEG-PLGA-OH can spontaneously assemble into nanoparticles in aqueous solution, with hydrophobic PLGA forming the core for encapsulating hydrophobic drugs, and hydrophilic mPEG forming the shell for stabilizing the nanoparticles.

In the field of drug delivery, it has applications that can be used to construct targeted drug carriers, achieve sustained release, controlled release, and precise delivery of drugs, improve therapeutic efficacy, and reduce side effects,

Can serve as building blocks for biomaterials and be applied in fields such as tissue engineering.

【 Related reagents 】

Folate-PEG-ACA

4-Arm PEG-CLS

CHO-Ph-PEG-STA

DSPE-PEG-SS-MAL

DSPE-PEG-TK-SH

DSPE-hyd-PEG-N3

DSPE-PEG-TK-Thiol

FA-PEG-Acrylamide

DSPE-PEG-TK-Acid

DSPE-PEG-TK-COOH

CHO-Ph-PEG-NH-Boc

DSPE-hyd-PEG-Azide

DSPE-PEG-SS-Maleimide

DSPE-hyd-PEG-Cyanine7

Aldehyde-Ph-PEG-NH-Boc

Aldehyde-Ph-PEG-Stearic acid

The above content is edited and organized by YNN of Xi'an Kaixin Biotechnology Co., Ltd

This reagent is only used for scientific research experiments and cannot be used on the human body

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