Epoxides-PEG-Catalase (Epoxy group-polyethylene glycol-catalase) is a functionalized bioconjugate that combines highly reactive epoxy groups, a hydrophilic polyethylene glycol (PEG) chain capable of prolonging half-life, and the key antioxidant enzyme—catalase. This design aims to enhance the stability, immunogenicity, and in vivo delivery efficiency of native enzymes.

Epoxides PEG Catalase is a functionalized biological conjugate that combines highly reactive epoxy groups, hydrophilic and half-life extending polyethylene glycol (PEG) chains, and the key antioxidant enzyme, catalase. This design aims to improve the stability, immunogenicity, and in vivo delivery efficiency of natural enzymes

Chinese name: Epoxide Polyethylene Glycol Catalase

英文名称： Epoxides-PEG-Catalase； Ep-PEG-Catalase； Catalase-PEG-Epoxides

分子量： 0.4k，0.6k，1k，2k，3.4k，5k，10k 等（支持定制）

Purity: ≥ 95%

Appearance: Solid powder or granules

Solubility: soluble in some organic solvents and water

Storage conditions: Freeze and dry below -20 ℃ to avoid repeated freeze-thaw cycles

Packaging specifications: 1g, 5g, 10g

Attention: When using, be sure to dry and avoid frequent dissolution and freeze-drying

Security protection:

During the operation, disposable protective clothing, masks and other protective equipment should be worn to ensure self safety.

Add image annotation, no more than 140 words (optional) [Application scenarios and cases]

Long term sustained release: high molecular weight (10k-20k) Epoxides PEG Catalase is used to construct hydrogel scaffold, which can continuously remove local H ₂ O ₂ and promote wound healing by slowly releasing Catalase.

tissue engineering

Medium molecular weight (3.4k-5k) Epoxides PEG Catalase is used as a scaffold material, which crosslinks with extracellular matrix proteins (such as collagen) through epoxide groups to form a three-dimensional network structure, supporting cell adhesion and proliferation.

biosensor

Using Catalase to catalyze the reaction of H ₂ O ₂, combined with chemical modification of epoxide groups, a high-sensitivity H ₂ O ₂ sensor is constructed for real-time monitoring of cell metabolism or environmental pollutants.

stability issue

Loss of enzyme activity

Chemical modification effects: Covalent binding between epoxy groups and enzymes may disrupt their active centers (such as heme cofactors), leading to a decrease in catalytic efficiency. For example, if the modification site is close to the catalytic site of the enzyme, it may directly block the binding of the substrate (H ₂ O ₂).

Environmental sensitivity: Although PEG chains can protect enzymes from protease degradation, high temperatures or organic solvents may damage the tertiary structure of enzymes, requiring strict control of storage conditions (such as low temperatures and neutral pH).

PEG chain detachment or degradation

Hydrolysis or enzymatic hydrolysis: PEG chains may break due to in vivo esterase or hydrolysis, leading to ineffective modification. For example, in long-term circulation, PEG may be metabolized by the liver or kidneys, shortening its half-life.

Crosslinking side reactions: Epoxy groups may undergo non-specific crosslinking with other molecules (such as plasma proteins), forming aggregates that affect drug distribution and clearance.

【 Related reagents 】

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DBCO-PEG-DSPE

Folalte-PEG-Biotin

COOH-PEG-PPHE

Cy5 carboxyl/Cy5 carboxyl

DSPE-PEG-Mannose

TPP-PEG-COOH/Carboxyl

Cy7 PEG azide/Cy7 PEG azide

CY5-PEG-DSPE CY5 PEG 磷脂

CY5 PEG 磷脂 CY5-PEG-DSPE

Biotin PEG DSPE Biotin PEG Phospholipids

Cyanine 7-VancomycinCy7-Vancomycin

Cy3-PEG2000-NH2Cy3-PEG2000-NH2

COOH-PRG-PGACOOH-PEG-PGA / COOH-PEG-PGA

Biotin-PEG2000-MannoseBiotin-PEG2000-Mannose

The above content is edited and organized by YNN of Xi'an Kaixin Biotechnology Co., Ltd

This reagent is only used for scientific research experiments and cannot be used on the human body

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