Flow chemistry synthesis system

Flow chemistry synthesis system

Flow chemistry (sometimes referring to intermittent flow, microchemistry, or continuous flow chemistry) innovatively integrates traditional independent and separate operational processes, accelerating the speed of research and development. Flow chemistry has emerged as a new production technology in the field of drug development. Flow chemistry reaction systems can quickly optimize reaction processes and synthesize large amounts of organic compounds, especially under high-risk and difficult to achieve reaction conditions, greatly promoting the development of green chemistry and laboratory automation. The flow chemistry reaction system is suitable for screening, optimizing, scaling up, and establishing chemical libraries in pharmaceutical chemistry, as well as organic chemistry research such as the synthesis of metal nanoparticles.

Flow chemistry synthesis systemTechnical Specifications:

Reaction temperature: -100 ℃~+250 ℃

Liquid phase reactor volume: 62.5 μ l, 250 μ l, 1ml, 4ml, 16ml

Solid phase reactor volumes: 0.7ml, 2.4ml, 5.6ml, 12ml

Pressure: 0-20bar (300psi)

流速: 1μl/min –10ml/min

Duration of stay: 1 second to several hours

Wetting component materials: Glass, PTFE, and PCTFE (both stainless steel and nickel alloy are acceptable)

Mixing: Rapid diffusion mixing

Production: micrograms to kilograms

Leakage automatic detection: automatic leakage diagnosis before operation

Automatic blockage detection: equipped with pressure sensor

Application of Flow Chemistry Synthesis:

Suzuki reaction: Faster reaction and improved selectivity, with negligible Pd content in the product

Hantzash pyrrole synthesis: improving reaction rate and yield, one-step process

Synthesis of metal nanoparticles: narrow particle size distribution, safe handling of corrosive reagents

N-alkylation to primary amines: faster reaction and significant monoalkylation selectivity