The Orbitrap Astral mass spectrometer combines the advantages of a highly selective quadrupole, a high dynamic range and resolution Orbitrap, and a fast and highly sensitive new Astral mass analyzer. The Orbitrap Astral mass spectrometer combines these three mass analyzers together and coordinates five independent ion beams in parallel within the instrument, setting a new standard for mass spectrometer performance and allowing for a deeper understanding of biology and pathogenesis from a new perspective.