Orbitrap Astral high-resolution mass spectrometer

NegotiableUpdate on 01/19

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Nature of the Manufacturer: Producers

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Overview

The Orbitrap Astral mass spectrometer combines the advantages of a highly selective quadrupole, a high dynamic range and resolution Orbitrap, and a fast and highly sensitive new Astral mass analyzer. The Orbitrap Astral mass spectrometer combines these three mass analyzers together and coordinates five independent ion beams in parallel within the instrument, setting a new standard for mass spectrometer performance and allowing for a deeper understanding of biology and pathogenesis from a new perspective.

Product Details

Realizing the goals of proteomics

Understand how the Orbitrap Astral mass spectrometer overcomes issues such as low flux, missing target analytes, and insufficient sensitivity, thereby promoting the further role of proteomics in drug discovery and translational research.

New standard for Data Independent Scanning (DIA)

The development goal of proteomics is to accurately measure thousands of proteins in thousands of samples. Due to the good reproducibility of mass spectrometry detection results, data independent scanning (DIA) combined with precise non-standard quantification (LFQ) technology has achieved deep coverage of the proteome. The Orbitrap Astral mass spectrometer has precise quantitative performance with higher flux, deeper coverage, and higher dynamic range, ensuring that the DIA method can provide high-quality data. Understand how the Orbitrap Astral mass spectrometer utilizes a revolutionary new DIA method applicable to the field of plasma proteomics for large-scale precision medical analysis.

The era of single-cell proteomics has arrived

Single cell proteomics can analyze the dynamic properties of the proteome of different types of cells in time and space. By detecting single-cell samples instead of large batch samples, resolution can be improved, facilitating a deeper understanding of the pathogenesis and basic biological processes, thus revealing complex biological characteristics. Understand how the Orbitrap Astral mass spectrometer achieves higher throughput and deeper coverage while ensuring precise quantification, thus opening up new horizons for single-cell proteomics research.

main advantages

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High throughput rapid detection

Expanding the sample queue requires increasing the flux. The Orbitrap Astral mass spectrometer is capable of high-throughput rapid detection, with a run time of 8 minutes per injection, which means it can analyze 180 samples per day. Not only is there a large number of samples for quantitative analysis, but for typical cell lysate samples, more than 8000 proteins can be identified with each injection. The Orbitrap Astral mass spectrometer can detect 180 samples in a day and identify over 1.4 million proteomes, undoubtedly opening up a new mode of proteomics research. This high-throughput rapid detection technology enables quantitative analysis of tens of thousands of samples within a year with just one mass spectrometer, expanding the scale of feasibility studies and improving statistical capabilities while providing new insights.

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higher sensitivity

The dynamic range of proteomics is very wide, which can not only quantitatively analyze high abundance proteins, but also detect proteins as low as several copies. The Orbitrap Astral mass spectrometer extends the dynamic range of protein quantification analysis from large volume samples to samples with only 200 copies/cell level. For applications with small sample sizes such as single-cell proteomics, the Orbitrap Astral mass spectrometer provides twice the flux and coverage compared to other mass spectrometry competitors with faster scanning speed and higher sensitivity, or three times the coverage with the same flux. These performance upgrades are due to the use of the same weight element labeling method in single-cell proteomics, which utilizes the high resolution and high-quality accuracy of the Orbitrap Astral mass spectrometer to further improve the flux by superimposing signals from multiple single cells in a single acquisition cycle of the mass spectrometer.

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Accurate quantification

Feasible insights require precise quantitative analysis of results. Although some biological processes or disease mechanisms may occur with two completely different changes, the vast majority only involve relatively weak perturbations, resulting in the elevation or lowering of some biomarkers, changing their positions or even affecting their structure and function, such as post-translational modifications or complex conformations. The Orbitrap Astral mass spectrometer not only achieves higher flux, deeper coverage, and higher sensitivity, but also generates high-quality data for precise quantitative analysis while completing all the aforementioned tasks. This increases the credibility of the results and ensures that every experiment performed can obtain truly valuable results through the use of methods such as LFQ or TMT.