Testing the defoaming performance of dimethyl silicone oil wrist oscillator

This wrist oscillator is specifically designed to test the defoaming performance of dimethyl silicone oil and meets the requirements of the United States Pharmacopeia

Technical parameters:

Distance: 13.3cm

Number of containers: 2 x 2

Frequency: 300rpm

Amplitude: adjustable from 0-15o

Timer (optional): 0.01s-99.99 minutes

Dimensions: 55 x 40 x 32cm

Attachment: Testing Method for Defoamer Performance of Dimethicone Silicone Oil (Simethicone) in the United States Pharmacopeia

Defoaming Activity
Foaming solution: 10 mg/mL of octoxynol 9 in water
Sample solution: 4 mg/mL of Simethicone in tertiary butyl alcohol. Shake vigorously.[Note—Warm slightly, if necessary, to dissolve. ]
Analysis
[Note—For each test, use a clean, unused, 250-mL glass jar. ]
Add, dropwise, 500 μL of the Sample solution to a clean, unused, cylindrical 250-mL glass jar, fitted with a 50-mm cap, containing 100 mL of the Foaming solution. Cap the jar, and clamp it in an upright position on a wrist-action shaker. Using a radius of 13.3 ± 0.4 cm (measured from the center of the shaft to the center of the bottle), shake for 10 s through an arc of 10 at a frequency of 300 ± 30 strokes/min. Record the time required for the foam to collapse. The time, in s, for foam collapse is determined at the instant the first portion of foam-free liquid surface appears, measured from the end of the shaking period.
Acceptance criteria: The defoaming activity time does not exceed 15 s.