Ultra high resolution mass spectrometry system

Orbitrap Astral ZoomUltra high resolution mass spectrometry system

Orbitrap Astral Zoom has reshaped a new peak in mass spectrometry technology. With its resolution, sensitivity, and high throughput, Astral Zoom not only meets current scientific research needs, but also provides unlimited possibilities for future scientific exploration.

Product Features:

• Higher throughput: 300 samples can be analyzed in a single day, reshaping the research throughput of large queues

The upgraded Astral quality analyzer can achieve a scanning speed of up to 270 Hz, combined with the Vanquish Neo UHPLC system and EASY Spray PepMap chromatographic column, identifying over 8200 proteomes from 200 ng Hela cell protease cut standards in a 4.8 minute gradient.

• Deeper coverage: Pre enrichment function improves sensitivity and protein coverage depth, aiding in further research in systems biology

By combining high-speed ion filters with curved traps, ion pre enrichment can be achieved. Combined with enhanced dynamic range (eDR) mode, a single injection can determine over 10000 proteomes and 200000 peptide segments, supporting more comprehensive protein sequence coverage and pathway annotation.

• Higher sensitivity: Enhanced low input mode and TMT HR mode improve the ability to analyze trace samples and promote high-throughput single-cell multi omics research

In low input mode, during LFQ DIA collection, over 6500 proteins can be identified from 250 pg of HeLa cell protease cleavage products, or an average of over 5800 proteins can be identified from HEK293F single cells. By using TMT Pro reagent for multiplex detection, high-throughput analysis of over 2000 single cells can be achieved in a single day, further improving the efficiency of single-cell proteomics research.

• More possibilities: high quantitative dynamic range, simultaneous quantification of high abundance and low abundance proteins with high quantitative accuracy and precision; Enhance the energy of step collision and improve the performance of mass spectrometry in cutting and cross-linking detection, thereby providing new information in structural biology; Higher sensitivity helps spatial genomics achieve deep coverage of proteins and metabolites, providing a more comprehensive understanding of the molecular basis of cellular tissues, signaling networks, and diseases.

Orbitrap Astral ZoomUltra high resolution mass spectrometry systemApplication Scenario:

• Proteomics: high-throughput single-cell proteomics, targeted pathway biology, immunopeptidomics

Metabolomics: single-cell metabolomics, SQUAD analysis, lipidomics

• Clinical research: clinical cohort studies, microbial host interactions, oncology applications

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