Introduction to the main structural composition and application of the eye drop filling linkage line:
1、 Core structure composition
1. Bottle sorting module
The disorderly empty bottles are automatically arranged in a directional manner through a rotary table bottle sorting machine, and are orderly conveyed to the cleaning station through a conveyor belt. Some models use robotic arm assisted positioning to ensure uniform bottle posture.
2. Cleaning and sterilization module
Physical cleaning: using high-pressure air washing or ultrasonic water washing technology to remove particles and surface pollutants inside the bottle.
Chemical sterilization: The tunnel type hydrogen peroxide sterilization box performs vacuum vaporization sterilization on the bottle body, and cooperates with the RABS (Restricted Access Barrier System) in the front and rear buffer zones to maintain a sterile environment, achieving a sealed cleaning, sterilization, and drying process.
3. Filling and packaging module
Filling unit: The ceramic plunger pump is used in conjunction with a weighing feedback system to achieve precise filling of trace amounts of liquid medicine. A chuck positioning device is installed below the filling head to ensure alignment of the bottle mouth.
Internal plug pressing: The cylinder drives the plug pressing mechanism, which precisely presses the internal plug arranged by the oscillator into the bottle mouth through a spring controlled double door structure.
• Cap sealing: The cap head is driven by a motor to rotate, and the anti rotation silicone block fixes the bottle body. The three jaw clamping mechanism completes the tightening of the outer cap under cylinder pressure, and the spring buffering design prevents damage to the bottle cap.
2、 Key technology applications
1. Aseptic assurance system
The entire line operates in a C-level clean environment, with key sealing areas covered by laminar flow hoods. Adopting 316L stainless steel material and a structure design with almost no dead corners, combined with "blowing and sealing" (BFS) technology or full RABS isolation, to minimize the risk of manual intervention pollution.
2. Intelligent control system
Based on PLC and human-machine interface, the whole line linkage control is implemented, with automatic monitoring, fault shutdown, and parameter numerical control adjustment functions. The visual inspection system can identify filling volume deviations or container defects in real time, which meets the requirements of GMP standardized production.
3. Flexible production adaptation
Modular design supports quick replacement and adjustment of parts, suitable for the production of various specifications of plastic bottles ranging from 3ml to 50ml. Single machines such as bottle sorting, filling, and capping can operate independently or be freely combined to meet different production capacity and process requirements.
3、 Industry application direction
The current equipment is widely used in the production of sterile preparations such as eye drops and nose drops, especially suitable for the packaging needs of new eye drops without preservatives. With the expansion of the preservative free formula market, the linkage line is promoting the upgrading of ophthalmic pharmaceuticals towards higher safety and intelligence through full process aseptic control technology and blockchain traceability system.