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Thermo Fisher Scientific (China) Co., Ltd
IC-MS combined technology helps you safeguard food safety
Date: 2025-12-19Read: 1
The rapid development of the economy and the doubling of the food industry have made "eating abundantly" the norm, but at the same time, they have amplified safety exposure: additives are used beyond limits and ranges, heavy metals, polar pesticide residues and other pollutants are widespread, and risks are spreading in a "chain like" manner. The traditional low flux and low sensitivity detection methods are no longer able to match the precise governance needs of "from farmland to dining table".
High throughput and highly sensitive food safety assurance tool!!!
——Thermo Fisher Ionic Chromatography Product Family
Ion chromatography (IC), as the preferred method for analyzing polar compounds, has become a designated testing method in multiple national standards, providing a comprehensive screening of raw materials and finished products, eliminating the "hidden dangers" associated with "eating well". But when the sample matrix is extremely complex and the toxicity of the tested harmful substances is high, requiring detection of ultra-low limits, Thermo Fisher's IC-MS or IC-ICP-MS combination system can be an ideal choice. The front-end still uses ion chromatography to achieve rapid separation and effectively eliminate interference, while the back-end uses mass spectrometry to achieve precise detection at the ppt level, targeting potential risk substances such as perchlorates, polar pesticide residues, and heavy metals, thus achieving a synergistic detection effect of "1+1>2".
IC-MS-MS-MS solution for polar pesticide residues containing anions and cations in food
Figure 1 Inuvion with RFID ion chromatography+TSQ triple quadrupole mass spectrometer
Figure 2 ppb level anionic polar pesticide residue IC-MS-MS-MS mass spectrum
(Click to view large image)
Figure 3 ppb level cationic polar pesticide residue IC-MS-MS-MS mass spectrum
(Click to view large image)
Figure 4 Schematic diagram of IC-MS-MS-MS combined flow path
(Click to view large image)
Program features:
● Good compatibility:Inuvion with RFID ion chromatography can seamlessly integrate with Thermo Fisher Scientific's entire range of single rod, tandem, and high-resolution mass spectrometry, all produced by Chromeleon ™ Unified platform control, easy to operate;
● Efficient desalination suppressor:The suppressor has a large capacity, thorough desalination, and produces pure water to ensure seamless connection between the IC effluent and the mass spectrometry ion source;
● High voltage resistance:Compatible with small particle size chromatography columns, compressing analysis time to the minute level, achieving rapid separation and detection of complex matrix samples;
● Detection limit:Meet the requirements of PPT level content polarity ion analysis.
IC-ICP-MS Solution for Elemental Speciation Analysis in Food
Figure 5 Inuvion ion chromatography+ICP-MS mass spectrometer
Figure 6 IC-ICP-MS combined technology for rapid and accurate analysis of chromium morphology
(Click to view large image)
Figure 7: Simultaneous Analysis of Iodine Forms in Food at ppb Level by IC-ICP-MS Combination
(Click to view large image)
Figure 8: Simultaneous quantification of ppb level methylmercury and inorganic mercury in food using IC-ICP-MS with a single injection (click to view larger image)
Program features:
Strong anti-interference ability:Inuvion ion chromatography uses all PEEK inert material, which can prevent secondary contamination of samples by Fe ³ ⁺ and Cr ³ ⁺ ions dissolved from metal systems such as stainless steel;
● Dual machine complementarity:IC first separates elements with different valence states, and then ICP-MS accurately detects them with PPT level sensitivity, achieving deep detection of "1+1>2";
● High sensitivity:After the combination of ion chromatography with enrichment capability and high-sensitivity ICP-MS, the detection of ultra trace metal forms can be easily achieved, meeting the strict requirements of food for detection limits as low as ppt level.
Summary:
The combination of IC-MS-MS and IC-ICP-MS: The front-end Inuvion series ion chromatography separates complex matrices, and the back-end mass spectrometry provides precise quantification at the ppt level, eliminating risks such as negative and positive polar pesticide residues, perchlorates, methylmercury, hexavalent chromium, arsenic, etc; The full PEEK flow path eliminates secondary pollution, Chromeleon ™ One click control, convenient operation, providing high-throughput and high-sensitivity full process protection from raw material screening to finished product release for "eating rich".