AS-TZ1 Transdermal Resistance Tester

Transdermal resistance testThe significance of

The administration route of drugs with local and systemic effects on the skin has received considerable attention in recent years. However, the main obstacle for drugs to penetrate the skin and exert their pharmacological activity is the inherent barrier of the skin, the stratum corneum (SC). The stratum corneum is the topmost layer of the skin, composed of keratinocytes filled with keratin and intercellular lipids. When conducting drug and cosmetic transdermal diffusion tests (IVPT) and in vitro efficacy evaluation of 3D epidermal models, visual and electrical impedance values (Trans Epidermal) are used Electrical Resistance (TEER) and Transdermal Water Loss (TEWL) were used as indicators to evaluate the functional integrity of in vitro skin slice models such as pig skin, mouse skin, and cultured skin. It is important to use skin model samples with qualified skin barrier to ensure the accuracy of the test results.

AS-TZ1sutraSkin resistance testerFeatures:

Evaluating and screening the barrier integrity of isolated skin by measuring electrical impedance can reduce

Data bias in drug transdermal absorption testing and cosmetic efficacy testing

The barrier function of skin samples can be evaluated through electrical impedance

The measurement time is a few seconds

By applying low-frequency communication, stable measurement values can be obtained

● Can display impedance and phase

● Powered by batteries, it can be used in various environments

Skin model impedance testerThe operational process

Slice the experimental skin to be tested (such as pig skin, mouse skin, and other animal ex vivo skin used in experiments, 3D recombinant epidermal models, etc.) between two chambers (such as the supply and receptor cells of the Franz diffusion cell), inject 0.9% NaCl solution into each chamber, and insert silver chloride electrodes into each chamber to measure the impedance between the electrodes. The evaluation method varies depending on the cells used. As a preparation for transdermal absorption experiments, the characteristics of the skin membrane used are evaluated and screened based on the results of electrical impedance measurements. In addition, stratum corneum cells with reduced barrier function often have lower impedance, and the biological skin barrier function is evaluated based on the electrical impedance of water and stratum corneum.

AS-TZ1 Transdermal Resistance TesterSpecifications

AS-TZ1 Transdermal Resistance TesterThe application

1. Research on the evaluation of in vitro skin integrity in the in vitro transdermal testing of formulations for topical and transdermal administration in the pharmaceutical industry

2. Screening of chemical penetration enhancers in the development of formulations for topical and transdermal drug delivery