Biox Aquaflux Transdermal Moisture Loss Analyzer

NegotiableUpdate on 01/04

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Nature of the Manufacturer: Producers

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Overview

The Biox Aquaflux transdermal water loss measuring instrument, like the open cavity method transdermal water loss measuring instrument, uses the method of measuring water diffusion in a stable state. However, in order to prevent the impact of outdoor air flow, the measurement chamber is a sealed room type structure. The temperature of the condenser is always kept below freezing point, which allows water vapor to condense here to ensure that water vapor does not accumulate in the chamber, thereby affecting continuous measurement.

Product Details

A healthy stratum corneum can effectively prevent the loss of moisture through the skin, limiting the amount of water lost through transdermal diffusion (excluding sweat and other forms of water loss) to around 500ml per day. However, when the skin barrier is damaged, the amount of transdermal water loss may increase by more than 30 times. Therefore, transepidermal water loss (TEWL) is closely related to skin barrier function and can serve as an auxiliary criterion for evaluating skin barrier integrity. TEWL is a commonly used method for detecting dehydration of the stratum corneum on the surface of the skin, used to evaluate the efficacy of cosmetics or drugs. In addition, TEWL is easy to operate in medical research and can be used to study skin diseases related to barrier function damage, such as psoriasis, atopic dermatitis, and burns. The European EEMCO has released revised guidelines for in vivo measurement of skin moisture content, which clearly states that TEWL can provide key information on skin physiology and barrier integrity, and has been widely used in various skin diseases and skin barrier function damage testing research.

Biox Aquaflux Transdermal Moisture Loss AnalyzerMeasuring principle
AquaFlux, like the open cavity transdermal water loss measuring instrument, uses the method of measuring water diffusion in a stable state. However, in order to prevent the impact of outdoor air flow, the measurement chamber is a sealed room type structure. The temperature of the condenser is always kept below freezing point, which allows water vapor to condense here to ensure that water vapor does not accumulate in the chamber, thereby affecting continuous measurement. The method of calculating TEWL using the condensation chamber method is consistent with the open chamber method, both of which are obtained by calculating the humidity gradient using two sets of dispersed humidity and thermometers. As shown in the figure below, one set of sensors is installed on the inner wall of the chamber near the skin side, while the other set of sensors is placed in the condenser.

feature
● High sensitivity, high repeatability, and high reproducibility
NPL approved metrological calibration
● High speed measurement and short waiting time between measurements
Regardless of the measurement location or angle
Not affected by the surrounding air flow
● Quickly install various measuring probes
● Adapter for various purposes such as face, scalp, lips, nails, etc
● Used for IVPT in vitro skin integrity experiments
● Used for cultivating skin tests
Biox Aquaflux Transdermal Moisture Loss AnalyzerTechnical Specifications

model	AquaFlux ™ Model AF200
Measuring principle	Closed chamber condensation chamber method
measurement parameters	TEWL、SSWL、 Temperature and relative humidity
Measurement object	Human, ex vivo skin, small animals, 3D cultured skin models, etc
measurement range	0～250.00g/m²/h
precision	TEWL：0.01g/m²/h SSWL: 0.0001g/m² Temperature: 0.1 ℃ Humidity: 0.1%
Probe size	165 (width) x 70 (depth) x 28 (height) mm
Probe weight	About 200g
power supply	Input: 90-260 Volt AC, 50-60 Hz Output: 5 Volt DC, 2 Amp max
External output	USB
data analysis software	Time curve recording of skin water diversion and loss of flux
operating system	Windows 7/10/11

application
1. Cosmetics manufacturers claim to conduct efficacy testing and research, such as acne removal, repair, soothing, moisturizing, etc.
2. Research and testing related to experimental animal skin disease models such as mice in the Medical Research Center (atopic dermatitis, psoriasis, eczema, photoaging, etc.).
3. Basic scientific research related to skin physiological barrier characterization in dermatology and cosmetic medicine research in medical schools.
4. Research on in vitro transdermal testing and evaluation of in vitro skin integrity in the development of formulations for topical and transdermal administration in the pharmaceutical industry.