Customization of laboratory biological fermentation equipment

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Customization of laboratory biological fermentation equipment

The fully automatic small glass fermentation device in the laboratory is widely used in microbiology laboratories of research institutes and enterprises, and is an ideal tool for precision fermentation experiments. Screening of culture medium formulas suitable for microbial fermentation cultivation, optimization of fermentation process parameters, and validation of production processes and strains. Especially coarse mash culture medium can adapt well.

1、 System composition:

Customization of laboratory biological fermentation equipment，The system mainly consists of fermentation tanks, air treatment systems, steam purification systems, electrical control systems, constant temperature systems and pipelines, valves, auxiliary systems, sensors and primary instrument systems, lower computer control systems (on-site PLC control system, secondary instruments), upper computer systems, and platforms.

2、 Technical parameters

4、 Fermentation System Configuration Checklist

Bidding parameters：

1. Laboratory fermentation tank

Tank structure: customized volume, off position sterilization, working pressure of 0.1Mpa; Main material: a combination of borosilicate glass and 316L stainless steel; Equipped with sampling and discharging valves for fermentation tanks, and standard interfaces such as air inlet, exhaust outlet, coil inlet and outlet, temperature probe port, pH probe port, DO probe port, defoaming interface, seed transfer port, and feeding port;

Loading coefficient: 70% -80%

Air intake filtration: using deep ventilation, with a large ventilation volume of 1.5VVM; Secondary filtration, precision 0.2 μ m Sartorius sterilization filter, capable of independent sterilization;

Motor: Motor power: 0.45KW, speed: 50-1000rpm, continuously adjustable and stable; Control accuracy ± 0.5% * high speed, resolution 1rpm;

Mixing: Top mechanical mixing system, using mixing shaft heat-treated stainless steel, precision machining, with ideal dynamic balance performance, good rigidity, and long-term use without deformation; Adopting adjustable mixing blades, with six flat blades on the upper gear and inclined blades on the lower gear, the special design can agitate the material settled at the bottom of the lower head to achieve uniform mixing effect. The first stage compression type high-efficiency defoaming blade and baffle are used;

★ Vaccination: Adopting the JD-D new automatic inoculation device, there is no possibility of bacterial contamination.

2. Control system

2.1 Temperature control system 1 set

2.1.1. Measurement range: 0-150 ℃;

2.1.2. Control range: room temperature ± 65 ℃;

2.1.3 Control accuracy: ± 0.2 ℃;

2.1.4 Resolution: 0.1 ℃;

2.1.5 Control content: Temperature value online detection, PID intelligent control, can be set according to the required temperature of the fermentation process.

2.1.6. Component selection: temperature sensor, SUS304 stainless steel electrode sheath, bottom heating plate for heating up, solenoid valve for cooling down.

★ 2.1.7. Features:

A) The PID intelligent control system ensures fast and energy-saving temperature control.

B) JD-WK3 chassis heating design.

2.1.8. Temperature band over upper and lower limit alarm function.

2.1.9. Software functions: data curve chart, data report, temperature manual and automatic control modes.

2.2 One set of pH online detection and control system

2.2.1 Control mode: fully automatic control, pH value can be set;

2.2.2. Display range: 0-14pH;

2.2.3. Control range: 2-12PH;

2.2.4 Resolution: 0.01pH;

2.2.5 Control accuracy: ± 0.02pH;

2.2.6 Control content: pH value online detection, PID intelligent control;

2.2.7 Component selection: glass gel pH electrode imported from Switzerland can be used for high temperature in place sterilization, 121 ℃ -30 minutes. Stainless steel electrode sheath, transmitter, and connected with original double shielded signal transmission line to ensure accurate pH control.

2.2.8. Execution mechanism: The microcomputer intelligent PID control system automatically adds acid or alkali to the two-way peristaltic pump, keeping the pH value within the set range. It can be controlled in both manual and automatic modes.

2.2.9. pH band upper and lower limit over limit alarm function.

2.2.10 Software functions: data curve chart, data report, pH manual and automatic control.

2.3 DO detection system 1 set

2.3.1. Detection method: automatic detection;

2.3.2. Display range: 0-100% or 0-200%;

2.3.3 Display accuracy: ± 0.1% or 1%;

2.3.4. Control content: Online detection of DO value;

2.3.5 Component selection: Swiss imported dissolved oxygen electrode detection, capable of high-temperature in-situ sterilization, 121 ℃ -30 minutes. Stainless steel electrode sheath and transmitter are connected using original double shielded signal transmission lines to ensure accurate DO display.

2.3.6. The system has a DO abnormal alarm function.

2.4 One set of pressure and flow control system

2.4.1. The diameter 60 surface pressure gauge indicates the pressure in the pipeline, tank, and jacket, and the tank pressure is manually controlled with a range of 0-0.25Mpa.

2.4.2. The glass rotor flowmeter manually controls the intake flow rate, and the ventilation volume can be adjusted.

2.5 Feeding system 1 set

2.5.1. Execution mechanism: Constant flow peristaltic pump flow addition.

2.5.2 Control mode: Automatic material feeding, with two control modes: manual and automatic. In automatic control mode, the amount of material fed per unit time can be set.

2.6 Bubble suppression system 1 set

2.6.1 Control mode: defoaming module, fully automatic control;

2.6.2. Control accuracy: 10-100000 Ω;

2.6.3 Control content: foam abnormal condition alarm, automatic intermittent processing;

2.6.4 Actuator: foam sensor detection, microcomputer automatic control peristaltic pump flow adding defoamer.

2.6.5 Control mode: manual and automatic control modes.

2.7 Speed control system 1 unit

Taiwan, China, China BC2000 DC speed governor, speed 50-1000rpm ± 1%, stepless frequency control.

2.8JD-BIO6000 lower computer fermentation process control system 1 set

2.8.17 "widescreen color LCD touch screen, programmable controller, laboratory fully automatic small glass fermentation device. One controller can simultaneously detect and control the corresponding parameters of the fermentation tank;

2.8.2 The biological fermentation process control system consists of an on-site controller, fermentation process control software, sensors, and various executing components. The on-site controller is based on a programmable controller, which adopts multi-level expansion and has sufficient A/D conversion channels, D/A conversion channels, and switch input and output for the system. The on-site controller adopts an industrial grade human-machine interface, and the fermentation system operates normally without an upper computer. This design structure and options better improve the reliability performance of the system.

2.8.3 The software control system adopts an advanced fuzzy control structure, which includes a lower level controller and software for on-site signal acquisition and transformation. In terms of control, intelligent PID control is adopted, with high control accuracy and parameter self-tuning control algorithm.

2.8.4 The on-site human-machine operation interface adopts a LCD touch screen, with advanced touch feel and a fully Chinese operation interface. It has functions such as digital setting, quick calibration, data storage, over limit alarm, and password setting.

2.8.5 The controller is equipped with a USB serial port, and users can copy the fermentation process parameter values and connect them to a printer on other computers for printing.

2.8.6 Function description of on-site control system:

1) Can detect and control the stirring speed, temperature, pH value of the fermentation tank;

2) The parameters of each detection and control circuit can be manually set and corrected online on the screen, and the operation has password protection function.

3) The adjustment method is PID, which can meet different control components and control performance, and can achieve manual/automatic disturbance free switching.

4) All kinds of monitoring data can be displayed and recorded in real-time, with display methods including trend lines and graphs,

5) Each circuit has upper and lower limit and alarm functions.

6) The system has a power-off protection function to protect data during power outages.

7) All operations are carried out on the human-machine interface, implementing visual operations.

8) The system has clock function: fermentation batch date, running time, etc.

9) The alarm can be cut off, which can be short-term or long-term.

10) Display the process of adding acid and alkali; It can achieve curve setting and manual and automatic control of pH value.

11) Temperature control: It can achieve curve setting and manually and automatically control the temperature value.

12) It has a display of the replenishment process and the total amount of replenishment.

13) It has defoaming function, records high foaming conditions, and displays the defoaming process.

14) The JD-CCK new remote monitoring system can be connected to a mobile phone to achieve remote monitoring and control of various parameters of the fermentation tank.

2.9 Complete set of electrical system and control cabinet

2.9.1. High quality electrical components, contactors, and intermediate relays are used, and the control systems of all tanks are integrated into the electrical control cabinet.

2.9.2. Slope control cabinet, surface spray coating, anti-static treatment, no interference;

2.9.3 Equipment cables (strong and weak), cable trays, cable fixing joints, etc.

★ 2.9.4. Provide the original manufacturer authorization and after-sales service commitment letter for this project. The technical parameters of the bidding product can be queried on the website or the original factory promotional brochure. Provide the product's inspection report and pictures

Complete set of valves, pipelines, and pipe fittings for 3 devices

The equipment pipeline system meets the requirements of microbial fermentation, and each pipeline is polished using pollution-free welding. All contact with materials is made of stainless steel pipes with internal and external precision polishing

4. One air compressor

Oil free air compressor, displacement: 60L/min, working pressure: 0.7Mpa, with built-in air storage tank.

5. Multi channel total gas production measurement system (optional)

1. Simultaneously monitoring multi-channel gases, with high cost-effectiveness. An instrument can simultaneously monitor multiple channels (6, 8, 10, 12)Gas flow rate, non interfering with each other.

2. Large range, low measurement limit, with a large range of up to 6000ml/h and a measurement limit as low as 1ml/day.

3. High measurement accuracy, especially for low flow gases, with a measurement accuracy CV ≤ 0.1%.

4. The instrument is simple and compact, with a small footprint, and can be operated on a laboratory bench.

5. The instrument comes with a touch screen display, and powerful software displays the accumulated gas flow rate and instantaneous gas production rate; Current data, historical dataThe data curve can be recorded, queried, and exported from a USB drive, with a user-friendly interface for operation.

6. Widely applicable, it can be used to measure the vast majority of inert gases and medium strength corrosive gases (such as biogas, hydrogen, biogas, etc.)

Our company（Beijing Jiade Precision Technology Co., Ltd）It is a professional engaged inIntegrated enterprise for the production, processing, and manufacturing of glass products, engineering plastics, and stainless steel tanks; The company has many years of manufacturing experience in glass products, plastic products, and stainless steel products; The company's main products include chromatography columns, stainless steel reaction vessels, high-pressure reaction vessels, glass fermentation tanks, stainless steel fermentation tanks, and related ancillary productsThe company is registered with the approval of relevant national departments. The company has been specializing in various fields for many yearsExperimental equipment, small-scale and pilot scale complete sets of equipment, and stainless steelThe production and assembly of equipment, such as the construction of plant active ingredient extraction workshops; Construction of a pilot plant for biological fermentationandColumn packing for chromatography、resin、Biological reagentsResearch and development. especially infermentation tankandIn terms of manufacturing chromatography columns, we have many years of production experience and our products have been exported to countries and regions such as the United States, Germany, South Korea, India, France, Israel, Japan, Singapore, and New Zealand. The company can provide safe and reliable experimental equipment and professional high-quality services according to the needs of different customers. We have always met the needs of domestic and international markets with high-quality and high-end products, discounted prices, and good reputation. Currently, universities, research institutions, government agencies, and enterprises in Beijing are using our products and have gained the trust of our customers!

Our company solemnly promises:

1. Product quality assurance, such as replacement for counterfeit products

2. Fast supply speed

3. Any damage caused during transportation shall be borne by our company

4. The company will provide excellent after-sales service