GMP Microfluidics

GMP microfluidic technology is a technique based on (micro) fluid mechanics theory that enables sample preparation and processing in pipelines. Combining the physical and chemical models of microfluidics with fluid mechanics theory can achieve functions such as mixing, emulsification, separation, and purification of samples.

　　GMP MicrofluidicsPreparation device description:

The MPE-L2 microfluidic control device is a microfluidic device that can be used for scientific research, early process validation, and technology development. Powered by an injection pump, experiments can be conducted with fewer samples. In addition, the innovative design of MPE-L2 supports multiple injections during the experiment.

The MPE-L3 microfluidic control preparation instrument is a microfluidic device that can be used for the preparation of chemical drugs and biological agents. Specially designed to conduct experiments with fewer samples; A processing capacity of no less than 20L/h meets the requirements for seamless integration of small-scale process development and pilot process validation. Save resources and improve efficiency.

　　GMP Microfluidicstechnology

1GMP MicrofluidicsMicrofluidic technology is a technique based on the theory of microfluidics that enables sample preparation and processing in pipelines. Combining the physical and chemical models of microfluidics with fluid mechanics theory can achieve functions such as mixing, emulsification, separation, and purification of samples.

2. Microfluidic technology combines Process Control Technology (PCT) with Process Analytical Technology (PAT) to achieve excellent Online Preparation Technology (OPT) for sample preparation. During the continuous preparation process, the parameters of the sample are controllable and have good reproducibility, making it more scalable compared to traditional stepwise and batch production methods.

3. It can achieve functions such as initial emulsification, re emulsification, and particle size control of the sample.

4GMP MicrofluidicsThe preparation system is connected to the microfluidic chip through a preparation pump and a high-pressure delivery pump. Phase A and phase B can be delivered to the chip at a constant speed in a certain proportion for mixing and emulsification. By designing different flow channel structures and controlling different speeds in microfluidic chips, the sample can achieve turbulent, laminar, or atomized states in the microfluidic chip, which can meet the requirements of sample colostrum or re emulsification.

5. The prepared sample is transported to a high-pressure microfluidic chip through a high-pressure pump, and the particle size is controlled by impact and shear forces to achieve the desired range. The minimum particle size can reach within 100nm, and the PDI is below 0.1.

　　GMP Microfluidicschip

　　GMP MicrofluidicsChips are customized special channel structure components based on application processes, and their channel structures and dimensions are combined with project process requirements, making them customized structural components. Specifically, the following four functions can be achieved:

1. Mixing and emulsification of two phases

2. Incubation after particle formation;

3. Particle size control after particle formation;

4. Secondary mixing or emulsification.

Technical Specifications: