Microfluidic control backup system

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Microfluidic control backup systemintroduction

EitzenMicrofluidic control backup systemPositioned in the scientific research and industrial technology application of micro nano formulations and complex injections, we provide mature and rich solutions for the scientific research and industrial application of different drug carriers such as Liposomes, LNPs, microemulsions, microcrystals, microspheres, etc. through specially designed microfluidic chips, highly integrated and systematic hardware systems (delivery pump systems, PAT toolkits, etc.), and process oriented humanized software systems. Devices and solutions based on Aitson microfluidic technology have been used in the development of multiple clinical drugs.

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Introduction to Microfluidic Technology

Microfluidic technology is a technique based on (micro) fluid mechanics theory that enables sample preparation and processing in pipelines. By combining the physical and chemical models of microfluidics with fluid mechanics theory, Midea can achieve functions such as mixing, emulsification, separation, and purification of samples.

Microfluidic technology combines Process Control Technology (PCT) with Process Analytical Technology (PAT) to achieve excellent Online Preparation Technology (OPT) for sample preparation. During the continuous preparation process, the parameters of the sample are fully controllable and have good reproducibility, making it more scalable compared to traditional stepwise and batch production methods.

It can achieve functions such as initial emulsification, re emulsification, and particle size control of the sample.

Microfluidic control backup systemBy preparing a pump and connecting it to a microfluidic chip with a high-pressure delivery pump, phase A and phase B can be delivered to the chip at a constant speed in a certain proportion for mixing and emulsification. By designing different flow channel structures and controlling different speeds in microfluidic chips, the sample can achieve turbulent, laminar, or atomized states in the microfluidic chip, which can meet the requirements of sample colostrum or re emulsification.

The prepared sample is transported to a high-pressure microfluidic chip through a high-pressure pump, and the particle size is controlled by impact and shear forces to achieve the desired range. The minimum particle size can reach within 100nm, and the PDI is below 0.1.

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Functional Application

♦Preparation of chemical drug liposomes,Such as Doxorubicin liposomes, Irinotecan liposomes, etc

♦Preparation of nucleic acid drug lipid nanoparticles,Such as mRNA LNP, siRNA LNP, etc

♦Preparation of polymer nanoparticles/microspheres, etc,Such as PLGA microspheres, PEG-PLGA nanoparticles, etc

♦Preparation of emulsion,Such as vaccine adjuvants, fat emulsion preparations, etc

♦Organic/inorganic nanoparticles,Like gold nanoparticles, etc

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Microfluidic control backup systemproduct

MPE-L2

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MPE-P1

MPE-L3