Pilot scale microfluidic control backup instrument

Pilot scale microfluidic control backup instrumentMPE-P1

Microfluidic Control Backup Instrument MPE-P1

The MPE-P1 microfluidic control preparation instrument is a pilot scale preparation system that can be used for the development of pilot scale preparation processes for micro nano formulations such as lipid nanoparticle LNP, polymer nanoparticles, liposome, microemulsion, etc., to assist in the industrial research of DDS systems for nucleic acid drugs and small molecule drugs. The device adopts an integrated touch screen operation, with system configuration of batch recording, data export and other functions, which is convenient and efficient. MPE-P1Pilot scale microfluidic control backup instrumentSupport the preparation of LNP, Liposome and other particles at high concentrations and high flow rates, with stable results and high reproducibility, providing detailed, reliable and comprehensive process data for production scaling up.

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Functional Application

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♦ Preparation of chemical drug liposomes, such as doxorubicin liposomes, irinotecan liposomes, etc;

♦Preparation of biological lipid nanoparticles (LNP), such as mRNA liposomes, siRNA liposomes, etc;

♦Preparation of polymer nanoparticles/microspheres, such as PLGA microspheres, PEG-PLGA nanoparticles, etc;

♦Preparation of emulsions, such as vaccine adjuvants, fat emulsion preparations, etc;

♦Organic/inorganic nanoparticles, such as gold nanoparticles;

♦Other related micro nano formulations.

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microfluidic chip

Microfluidic chips are customized special channel structure components based on application processes, whose channel structure and size are combined with project process requirements, and belong to customized structural components. Specifically, the following four functions can be achieved:

① Mixing and emulsification of two phases;

② Incubation after particle formation;

③ Particle size control after particle formation;

④ Secondary mixing or emulsification.

Typical chip

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Technical Specifications

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Introduction to Microfluidic Technology

Microfluidic technology is a technique based on (micro) fluid mechanics theory that enables sample preparation and processing in pipelines. By combining the physical and chemical models of microfluidics with fluid mechanics theory, Midea can achieve functions such as mixing, emulsification, separation, and purification of samples.

Microfluidic technology combines Process Control Technology (PCT) with Process Analytical Technology (PAT) to achieve excellent Online Preparation Technology (OPT) for sample preparation. During the continuous preparation process, the parameters of the sample are fully controllable and have good reproducibility, making it more scalable compared to traditional stepwise and batch production methods.

It can achieve functions such as initial emulsification, re emulsification, and particle size control of the sample.

The microfluidic control preparation system is connected to the microfluidic chip through a preparation pump and a high-pressure delivery pump. Phase A and phase B can be delivered to the chip at a constant speed in a certain proportion for mixing and emulsification. By designing different flow channel structures and controlling different speeds in microfluidic chips, the sample can achieve turbulent, laminar, or atomized states in the microfluidic chip, which can meet the requirements of sample colostrum or re emulsification.

The prepared sample is transported to a high-pressure microfluidic chip through a high-pressure pump, and the particle size is controlled by impact and shear forces to achieve the desired range. The minimum particle size can reach within 100nm, and the PDI is below 0.1.