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Pddry1@163.com
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13915023276
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No.1 Village South Road, Shijia Lane, Zhenglu Town, Tianning District, Changzhou City
Product Categories
Jiangsu Pengduo Machinery Technology Co., Ltd
Spray drying granulator
NegotiableUpdate on 02/05
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Overview
PGL-B series spray drying granulator is a new one-step granulator integrating spray drying technology and fluidized bed granulation technology. It uses a negative pressure suction of the induced draft fan to dry the droplets, aggregate them into particles, and can adjust the particle size according to requirements.
Product Details
1、 Product Features
1. The structure of spray drying chamber, capture chamber, fluidized bed and secondary air supply system has been significantly modified, which more closely shows the characteristics of spray drying.
2. Realize continuous spray process of the extract.
3. Design, manufacture, and layout in accordance with GMP requirements.
4. Easy to operate and reliable.
5. Improve spray drying efficiency.
6. More stable than FL type fluidization, more reasonable adjustment of air volume, improved fluidization drying intensity, and overcame the "dead bed" phenomenon
7. Multi fluid atomizer, more suitable for products with high sugar content, strong viscosity or heat sensitivity.
2、 Fluidized bed spray method
In the process of fluidized bed granulation or pellet making and coating, the spray method should be selected according to the material performance and planned product quality. At present, there are three methods of fluidized bed spray, namely top spray, tangent spray and bottom spray.
(1) Top spray
Most products that coalesce in fluidization are produced using this method, and the particles produced are characterized by porous surfaces and interstitial voids, with a low bulk density. It is an effective method to increase the solubility of insoluble drugs because particles or pellets are prone to absorbing liquids and disintegrate quickly, such as in the drying and granulation of traditional Chinese medicine extracts.
(2) Tangent spray
It utilizes the centrifugal force generated by the rotation of the turntable to achieve high-strength mixing effect, combined with the drying efficiency of the fluidized bed, thereby producing products with high bulk density but still a small amount of gaps and voids. The particles have high hardness, are not easy to break, and are close to spherical shape, which is a common method for preparing microspheres.
(3) Bottom end spray
Set the nozzle in the guide tube at the center of the airflow distribution plate, and the fluidized particles, microspheres, or tablets receive adhesive or coating solution in the guide tube. It is currently the most commonly used method for coating microspheres, with the advantages of high coating efficiency and low adhesion of microspheres. Xinyi Special has developed an improved fluidized bed that can adjust the internal and external air volume of the draft tube online, and can clean the spray device online, greatly improving the controllability of the fluidized bed pellet coating.
The above three spray methods can be used for the preparation and coating of particles and pellets in fluidized beds, but the tablet coating is only limited to the bottom spray type. The core of fluidized-bed granulation and coating process is the liquid spray system. In almost all fluidized-bed equipment, the role of nozzle is dual, namely granulation and coating. The liquid is ejected through an orifice under low pressure and atomized by the air flow. This nozzle can produce small droplets, which is an advantage for the coating of particles or pellets, but it also brings about an increase in the evaporation surface. The small droplets quickly transform into solid concentrate in the process of moving forward, and their viscosity also increases. If the spray speed, solution concentration and fluidization temperature are not matched properly, some small droplets cannot spread evenly when contacting the surface of particles or pellets, forming incomplete films or uneven forming of particles and pellets, or even forming adhesives or coating materials drying into particles or pellets, resulting in unstable or unstable product quality Qualified. If the solvent evaporation heat of the atomized solution is low, this problem will become more severe.
3、 Equipment features
1. It adopts spray process, especially suitable for micro auxiliary materials and heat sensitive materials, and its efficiency is 1-2 times higher than that of FL boiling granulator;
2. It integrates the functions of mixing, spray drying, granulation and particle coating;
3. Can be used for granulation of micro excipients, small doses, low sugar or sugar free preparations;
4. The final moisture content of the product can reach 0.1%, equipped with a powder return device, with a granulation rate of ≥ 95%, and can produce 0.2-2mm particles;
5. The particles produced are instant, the granules are easy to dissolve, and the tablets are easy to disintegrate;
6. Using liquid materials as wetting adhesives can save a lot of alcohol;
7. The equipment operates under sealed negative pressure, with a smooth inner surface that meets GMP requirements;
8. The automation process has been further improved, making it easy to operate and effectively ensuring the stability of product quality;
9. Improved design of internal mixed multi fluid atomizer, capable of processing paste with a specific weight of 1.3g/cm3;
4、 Working principle:
First, add a certain amount of seeds (dry powder matrix) to the material: pass hot air to make the seeds boil and dry; Add paste liquid through atomizer; Continue to circulate hot air while boiling and drying, while granulation, until the addition of the paste stops and the particles meet the drying requirements.
5、 Application scope:
1. Medicine: Liquid extract, vitamins, animal glue, plant glue, yeast, protease, lipase, amylase, etc
2. Food, dairy and egg products: butter, high-fat milk powder, milk replacer powder, egg white (yellow) and other plant-based juices;
3. Food plant juice: chicken essence, coffee, instant tea, fish and pork protein, potato, soybean, peanut protein, etc.
4. Carbohydrates: corn, corn starch, glucose, pectin, potassium sorbate, maltose, etc.
5. Detergents: emulsifiers, whitening agents, dispersants, baking soda, soap powder, phosphate agents, regular laundry detergent, high-efficiency laundry detergent, etc.
6. Chemical industry: dyes, pigments, resins, white carbon black, ceramics, etc.
7. Other industries: pesticides, feed, fertilizers, pigments, dyes, etc.
